Evidence map›Paper›PMID 29663798›Full record

ArticleACS infectious diseases2018

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.

Matthew R Bockman, Curtis A Engelhart, Surendra Dawadi, Peter Larson, Divya Tiwari, David M Ferguson, Dirk Schnappinger, Courtney C Aldrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. ACS infectious diseases · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Matthew R BockmanDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Curtis A EngelhartDepartment of Microbiology and Immunology , Weill Cornell Medical College , 1300 York Avenue , New York , New York 10021 , United States.
Surendra DawadiDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Peter LarsonDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.
Divya TiwariDepartment of Microbiology and Immunology , Weill Cornell Medical College , 1300 York Avenue , New York , New York 10021 , United States.
David M FergusonDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.ORCID 0000-0001-6294-8057
Dirk SchnappingerDepartment of Microbiology and Immunology , Weill Cornell Medical College , 1300 York Avenue , New York , New York 10021 , United States.
Courtney C AldrichDepartment of Medicinal Chemistry , University of Minnesota , 308 Harvard Street SE , Minneapolis , Minnesota 55455 , United States.ORCID 0000-0001-9261-594X
University of Minnesota · USCornell University · US

Funding

Biotin synthesis and biotin ligation in MtbR01AI091790 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHNAPPINGER, DIRK · 2011 to 2015
$3.0M
iTC200 MicroCalorimetry Cell Control UnitS10OD017982 · OD · UNIVERSITY OF MINNESOTA · PI ALDRICH, COURTNEY C · 2014 to 2014
$94k
NIAID NIH HHS R01 AI091790NIH HHS S10 OD017982
6 · The paper itself

Abstract

5'-[ N-(d-biotinoyl)sulfamoyl]amino-5'-deoxyadenosine (Bio-AMS, 1) possesses selective activity against Mycobacterium tuberculosis ( Mtb) and arrests fatty acid and lipid biosynthesis through inhibition of the Mycobacterium tuberculosis biotin protein ligase ( MtBPL). Mtb develops spontaneous resistance to 1 with a frequency of at least 1 × 10

Indexed as

Drug Resistance, BacterialAntitubercular AgentsCarbon-Nitrogen LigasesMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisNucleosidesStructure-Activity RelationshipSubstrate SpecificityAntitubercular AgentsCarbon-Nitrogen LigasesNucleosidesadenylationbiotin protein ligasebisubstrate inhibitormetabolismMycobacterium tuberculosistuberculosis

Identifiers

PMID29663798
PMCPMC13325200
OpenAlexW2799966839

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.