ArticleHippocampus2018
Adult neurogenesis affects motivation to obtain weak, but not strong, reward in operant tasks.
Article in Hippocampus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Separate orexigenic hippocampal ensembles shape dietary choice by enhancing contextual memory and motivation.Nature metabolism · 2025Article
- Conditioned overconsumption is dependent on reinforcer type in lean, but not obese, mice.Appetite · 2024Article
- Article
- A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology.Molecular psychiatry · 2022Review
- Hippocampal neurogenesis promotes preference for future rewards.Molecular psychiatry · 2021Article
- A Runner's High for New Neurons? Potential Role for Endorphins in Exercise Effects on Adult Neurogenesis.Biomolecules · 2021Review
- Adult neurogenesis alters response to an aversive distractor in a labyrinth maze without affecting spatial learning or memory.Hippocampus · 2021Article
- Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility.Nature communications · 2020Article
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
- The Effects of Anesthesia on Adult Hippocampal Neurogenesis.Frontiers in neuroscience · 2020Article
- Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders.Frontiers in neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Decreased motivation to seek rewards is a key feature of mood disorders that correlates with severity and treatment outcome. This anhedonia, or apathy, likely reflects impairment in reward circuitry, but the specific neuronal populations controlling motivation are unclear. Granule neurons generated in the adult hippocampus have been implicated in mood disorders, but are not generally considered as part of reward circuits. We investigated a possible role of these new neurons in motivation to work for food and sucrose rewards in operant conditioning tasks using GFAP-TK pharmacogenetic ablation of adult neurogenesis in both rats and mice. Rats and mice lacking adult neurogenesis showed normal lever press responding during fixed ratio training, reward devaluation, and Pavlovian Instrumental Transfer, suggesting no impairment in learning. However, on an exponentially progressive ratio schedule, or when regular chow was freely available in the testing chamber, TK rats and mice showed less effort to gain sucrose tablets. When working for balanced food tablets, which rats and mice of both genotypes strongly preferred over sucrose, the genotype effects on behavior were lost. This decrease in effort under conditions of low reward suggests that loss of adult neurogenesis decreases motivation to seek reward in a manner that may model behavioral apathy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.