ArticleEuropean journal of heart failure2018
Adiposity, body composition and ventricular-arterial stiffness in the elderly: the Atherosclerosis Risk in Communities Study.
Article in European journal of heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Highlights in heart failure.ESC heart failure · 2019Pooled it
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- Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors.Cardiovascular diabetology · 2025Article
- Chinese visceral adipose index is more closely associated with risk of arterial stiffness than traditional obesity indicators: a cohort study.Diabetology & metabolic syndrome · 2024Article
- Examining temporal changes in model-optimized parameters using longitudinal hemodynamic measurements.Biomedical engineering online · 2024Article
- Obesity and heart failure with preserved ejection fraction: new insights and pathophysiological targets.Cardiovascular research · 2023Review
- Abnormal left ventricular systolic reserve function detected by treadmill exercise stress echocardiography in asymptomatic type 2 diabetes.Frontiers in cardiovascular medicine · 2023Article
- Short Video Viewing, and Not Sedentary Time, Is Associated with Overweightness/Obesity among Chinese Women.Nutrients · 2022Article
- Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications.Physiological reviews · 2021Review
- Cardiac Function Normalizes 1 Year After Bariatric Surgery in Half of the Obesity Patients with Subclinical Cardiac Dysfunction.Obesity surgery · 2021Article
- Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow.Cell death discovery · 2021Article
- Radiation exposure after myocardial perfusion imaging with Cadmium-Zinc-Telluride camera versus conventional camera.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Shared genetic etiology and causality between body fat percentage and cardiovascular diseases: a large-scale genome-wide cross-trait analysis.BMC medicine · 2021Article
- The relationship between changes in deoxy Hb and body composition before and after cycling exercise during unilateral lower extremity occlusion.Journal of physical therapy science · 2021Article
- Stiffness of aortic arch and carotid arteries increases inAmerican journal of translational research · 2021Article
- Heart failure in the last year: progress and perspective.ESC heart failure · 2020Review
- Obesity and the heart: The impact of obesity beyond the body mass index.European journal of preventive cardiology · 2020Article
- Article
- Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects.International journal of molecular sciences · 2020Article
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9 authors at 3 institutions in 1 country.
Funding
Abstract
aimWeight gain appears to accelerate age-related ventricular-arterial stiffening, which has been implicated in the development of heart failure (HF), but it is unclear whether body fat accumulation underpins this association. We evaluated the relationship of adiposity, using measures of body composition, with ventricular-arterial stiffness among the elderly in the community. METHODS AND
resultsAdiposity was accessed through body mass index (BMI), waist circumference, and body fat percentage. We studied the association of these measures with carotid-femoral pulse wave velocity (cfPWV), arterial elastance index (EaI), left ventricular (LV) end-systolic elastance index (EesI) and LV end-diastolic elastance index (EedI) in 5520 community-based, elderly Atherosclerosis Risk in Communities (ARIC) Study participants, who underwent echocardiography between 2011 and 2013. BMI and waist circumference were directly associated with EaI, EedI and EesI even after adjusting for age, sex, race, hypertension, diabetes mellitus, heart rate, prevalent coronary heart disease and HF. After further adjustment for BMI, body fat percentage demonstrated significant independent linear relationships with EaI [standardized beta coefficient (β)=0.17, P<0.001], EesI (β=0.08, P=0.003) and EedI (β=0.20, P<0.001), and significant non-linear relationships with cfPWV (P=0.033).
conclusionIn this biracial community-based cohort, increased adiposity was associated with increased ventricular-arterial stiffness among the elderly and suggests a potential mechanism by which obesity might contribute to the development of HF.
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