Observational studyClinical cardiology2018
Frequent atrial premature complexes during exercise: A potent predictor of atrial fibrillation.
Observational study in Clinical cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.
- Prognostic implications of stress test-induced arrhythmias: a systematic review and meta-analysis.Open heart · 2025Pooled it
- Brazilian Guideline for Exercise Test in the Adult Population - 2024.Arquivos brasileiros de cardiologia · 2024Guideline
- Frequent atrial premature complexes during exercise: A potent predictor of atrial fibrillation.Clinical cardiology · 2018Observational
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical significance of atrial premature complexes (APCs) during exercise is unclear. HYPOTHESIS: Frequent APCs during exercise provides prognostic information.
methodsA total of 998 patients were divided into 2 groups based on the presence of frequent APCs during treadmill testing (>5 beats per stage): the FAPC group (n = 128) vs the non-FAPC group (n = 870). The primary outcome was new-onset atrial fibrillation or flutter (AF/AFL) during follow-up period (356.2 ± 131.1 days).
resultsMean age was 56.0 ± 10.2 years in the FAPC group and 52.6 ± 12.0 years in the non-FAPC group (P = 0.001). Baseline electrocardiographic and echocardiographic findings were not significantly different between the 2 groups. During exercise, maximal heart rate did not differ between the 2 groups. Chronotropic incompetence was more prevalent in the FAPC group than in the non-FAPC group (P = 0.04). During follow-up, the FAPC group had a higher incidence of AF/AFL than did the non-FAPC group (7 patients [5.5%] vs 5 patients [0.6%]; P < 0.001). Treadmill-induced frequent APCs (adjusted hazard ratio [HR]: 15.23, 95% confidence interval: 4.59-50.56, P < 0.001), chronotropic incompetence (adjusted HR: 19.95, 95% CI: 6.02-66.10, P < 0.001), and palpitation as a reason for treadmill testing (adjusted HR: 5.72, 95% CI: 1.64-20.00, P = 0.01) were independent risk factors that predicted new-onset AF/AFL.
conclusionsFrequent APCs during treadmill testing was associated with development of AF/AFL in this study. Close monitoring for further AF/AFL development is needed in these patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.