Evidence map›Paper›PMID 29663451›Full record

ReviewClinical cardiology2018

Association of prolonged QTc interval with Takotsubo cardiomyopathy: A neurocardiac syndrome inside the mystery of the insula of Reil.

Vincenzo Marafioti, Giulia Turri, Vincenzo Carbone, Salvatore Monaco

Abstract readReview
In one paragraph

Review in Clinical cardiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022
    Pooled it
  2. Article
  3. Review
  4. Review
  5. QTc interval measurement in patients with right bundle branch block: A practical method.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
    Article
  6. Article
  7. Mental Stress and Cardiovascular Health-Part I.Journal of clinical medicine · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Vincenzo MarafiotiCardiovascular and Thoracic Department, University Hospital of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-1943-025X
Giulia TurriDepartment of Neurological and Movement Sciences, University Hospital of Verona, Verona, Italy.
Vincenzo CarboneDepartment of Medicine and Pharmacology, University Hospital of Messina, Messina, Italy.
Salvatore MonacoDepartment of Neurological and Movement Sciences, University Hospital of Verona, Verona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Takotsubo cardiomyopathy is often considered autochthonous to the heart, although the primary problem may be not in the heart muscle itself. Instead, similar to several Takotsubo-like cardiac pathologies seen in acute neurological diseases, it may reflect the capacity of the nervous system to injure the heart. Persuasive evidence exists that shocking emotional stress promotes direct heart injuries. Moreover, clinical and laboratory research shows that cardiac structural damage can occur in the presence of a normal heart, especially in the context of seizures, stroke, and traumatic brain injury or under conditions of psychological stress. The aim of this review is to summarize the clinical implications of these observations, several of which focus on the pivotal role of the insula of Reil in the brain-heart connection, to unravel the mystery of Takotsubo cardiomyopathy pathogenesis.

Indexed as

Heart RateVentricular Function, LeftAction PotentialsAnimalsCerebral CortexHeartHumansPrognosisRisk FactorsStress, PsychologicalTakotsubo CardiomyopathyInsula of ReilQTc IntervalTakotsubo CardiomyopathyVentricular Repolarization

Identifiers

PMID29663451
PMCPMC6490097

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.