Evidence map›Paper›PMID 29663426›Full record

ArticlePhotochemistry and photobiology2018

Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo.

Kayla Marra, Ethan P LaRochelle, M Shane Chapman, P Jack Hoopes, Karina Lukovits, Edward V Maytin, Tayyaba Hasan, Brian W Pogue

Abstract readComparative Study
In one paragraph

Article in Photochemistry and photobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Review
  4. Article
  5. Measurements of illuminance in simulated daylight photodynamic therapy.Photodermatology, photoimmunology & photomedicine · 2022
    Article
  6. Review
  7. Effect of Different Wavelengths of Laser Irradiation on the Skin Cells.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kayla MarraThayer School of Engineering, Dartmouth College, Hanover, NH.
Ethan P LaRochelleThayer School of Engineering, Dartmouth College, Hanover, NH.ORCID 0000-0002-7883-9987
M Shane ChapmanDepartment of Surgery, Geisel School of Medicine, Hanover, NH.
P Jack HoopesDepartment of Surgery, Geisel School of Medicine, Hanover, NH.
Karina LukovitsThayer School of Engineering, Dartmouth College, Hanover, NH.
Edward V MaytinDepartment of Biomedical Engineering, Learner Research Institute, Cleveland Clinic Foundation, Cleveland, OH.
Tayyaba HasanWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, NH.
Dartmouth College · USCleveland Clinic · USHarvard University · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Bryan Quilty Spring · 2001 to 2026
$27.9M
NCI NIH HHS P01 CA084203NCI NIH HHS P30 CA023108
6 · The paper itself

Abstract

Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery. A total PpIX-weighted fluence of 20 J

Indexed as

LightingPhotochemotherapySunlightAdministration, TopicalAminolevulinic AcidAnimalsBiological AssayColorDose-Response Relationship, RadiationKeratosis, ActinicMiceModels, BiologicalPhotobleachingPhotosensitizing AgentsSkinSTAT3 Transcription FactorAminolevulinic AcidPhotosensitizing AgentsStat3 protein, mouseSTAT3 Transcription Factor

Identifiers

PMID29663426
PMCPMC6135665
OpenAlexW2800491017

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.