ReviewJournal of cellular physiology2018
Regulatory T and T helper 17 cells: Their roles in preeclampsia.
Review in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of IL-17 and IL-27 polymorphisms with susceptibility to recurrent pregnancy loss and pre-eclampsia: A systematic review and meta-analysis.Immunity, inflammation and disease · 2023Pooled it
- Pooled it
- Modulation of Immune Cells by Aspirin During Pregnancy.Immunology · 2026Observational
- Leveraging PANoptosis-associated genes for unraveling implication of decidualization deficiency in pre-eclampsia via transcriptome data and experiment validation.Frontiers in cell and developmental biology · 2026Article
- Regulation of PI3K/Akt in preeclampsia: an examination of its pathological role and therapeutic potential.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Dysregulation of Treg/Th17 Balance and Intracellular Expression of IL-21 and IL-22 in the Pathogenesis of Gestational Hypertension.Journal of clinical medicine · 2025Article
- The impact of GnRH agonists on endometrial immune cells in patients with adenomyosis: a prospective cohort study.BMC medicine · 2025Article
- Inflammatory markers in pregnancy - identifying drivers in four large cohorts.Frontiers in immunology · 2025Article
- The Hidden Relationship between Intestinal Microbiota and Immunological Modifications in Preeclampsia Pathogenesis.International journal of molecular sciences · 2024Review
- Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia.Journal of pregnancy · 2024Article
- Development and validation of nomograms to predict clinical outcomes of preeclampsia.Frontiers in endocrinology · 2024Article
- Examining the Aryl Hydrocarbon Receptor Network in the Placental Tissues of Pregnancies Complicated by Pre-Eclampsia: An Explorative Case-Control Analysis.Life (Basel, Switzerland) · 2023Article
- Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia.Journal of translational medicine · 2023Article
- The role of immune cells and mediators in preeclampsia.Nature reviews. Nephrology · 2023Review
- Preeclampsia-Derived Exosomes Imbalance the Activity of Th17 and Treg in PBMCs from Healthy Pregnant Women.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Pre-eclampsia.Nature reviews. Disease primers · 2023Review
- CD8 and CD4 Positive NKT Subpopulations and Immune-Checkpoint Pathways in Early-Onset Preeclampsia and Healthy Pregnancy.International journal of molecular sciences · 2023Article
- IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies.International journal of molecular sciences · 2022Review
- Human Chorionic Villous Differentiation and Placental Development.International journal of molecular sciences · 2022Review
- Regulatory T Cell Apoptosis during Preeclampsia May Be Prevented by Gal-2.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory T (Treg) cells have been identified as key immune regulators and are important to fetal survival within the maternal uterus. T helper 17 (Th17) cells have also emerged as a new subset of effector helper T cells and play significant roles in host defense against extracellular pathogens, autoimmune conditions, and inflammatory chronic diseases. Recent findings have provided strong support for the contribution of Th17 and Treg cells to successful pregnancy. Disorders of pregnancy such as preeclampsia (PE) and recurrent spontaneous abortion (RSA) are associated with low frequencies of Treg cells and high levels of Th17 cells. Here, we review current knowledge on Tregs and Th17 cells and shed light on their roles in both normal pregnancy and PE. We also discuss the imbalance between Th17 cells and Treg cells which is known as a major contributory factor in the pathophysiology of PE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.