Evidence map›Paper›PMID 29663330›Full record

Trial reportThe British journal of surgery2018

Multicentre phase II trial of near-infrared imaging in elective colorectal surgery.

F Ris, E Liot, N C Buchs, R Kraus, G Ismael, V Belfontali, J Douissard, C Cunningham, I Lindsey, R Guy and 7 more

2 registry-linked trialsOpen access · hybridAbstract readClinical Trial, Phase IIMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The British journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 105 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 16 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02459405 phase2completednot on this map

Decreasing Leak Rate in Colorectal Surgery Using Near Infra-red (NIR) Imaging: a Multicentric Prospective Phase II Study

TypeinterventionalSponsorUniversity Hospital, GenevaRan2013 to 2016Enrolled504ConditionsAnastomotic LeakArmsNIR anastomotic perfusion assessment, Near infrared camera
NCT05734118 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Indocyanine Green Fluorescence Angiography Mediated Assessment of Gastro-Intestinal Perfusion in Neonates

TypeinterventionalSponsorUniversity Medical Center GroningenRan2023 to 2024Enrolled20ConditionsNEC, Atresia, Malrotation, Intestinal PerforationArmsPerfusion assessment by means of the SPY-PHI camera
3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 16 syntheses or guidelines pooled it, 197 citations in OpenAlex.

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  8. Intraluminal Anastomotic Assessment Using Indocyanine Green Near-Infrared Imaging for Left-Sided Colonic and Rectal Resections: a Systematic Review.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 3 countries.

F RisDepartment of Surgery, Service of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.ORCID 0000-0001-7421-6101
E LiotDepartment of Surgery, Service of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
N C BuchsDepartment of Surgery, Service of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
R KrausDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
G IsmaelDepartment of Surgery, Mater Misericordiae University Hospital, and Section of Surgery and Surgical Sciences, University College Dublin, Dublin, Ireland.
V BelfontaliDepartment of Surgery, Service of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
J DouissardDepartment of Surgery, Service of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
C CunninghamDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
I LindseyDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
R GuyDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
O JonesDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
B GeorgeDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
P MorelDepartment of Surgery, Service of Visceral Surgery, Geneva University Hospitals and Medical School, Geneva, Switzerland.
N J MortensenDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
R HompesDepartments of Colorectal Surgery, Oxford University Hospitals, Oxford, UK.
R A CahillDepartment of Surgery, Mater Misericordiae University Hospital, and Section of Surgery and Surgical Sciences, University College Dublin, Dublin, Ireland.
Near-Infrared Anastomotic Perfusion Assessment Network VOIR
Oxford University Hospitals NHS Trust · GBUniversity Hospital of Geneva · CHUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDecreasing anastomotic leak rates remain a major goal in colorectal surgery. Assessing intraoperative perfusion by indocyanine green (ICG) with near-infrared (NIR) visualization may assist in selection of intestinal transection level and subsequent anastomotic vascular sufficiency. This study examined the use of NIR-ICG imaging in colorectal surgery.

methodsThis was a prospective phase II study (NCT02459405) of non-selected patients undergoing any elective colorectal operation with anastomosis over a 3-year interval in three tertiary hospitals. A standard protocol was followed to assess NIR-ICG perfusion before and after anastomosis construction in comparison with standard operator visual assessment alone.

resultsFive hundred and four patients (median age 64 years, 279 men) having surgery for neoplastic (330) and benign (174) pathology were studied. Some 425 operations (85·3 per cent) were started laparoscopically, with a conversion rate of 5·9 per cent. In all, 220 patients (43·7 per cent) underwent high anterior resection or reversal of Hartmann's operation, and 90 (17·9 per cent) low anterior resection. ICG angiography was achieved in every patient, with a median interval of 29 s to visualization of the signal after injection. NIR-ICG assessment resulted in a change in the site of bowel division in 29 patients (5·8 per cent) with no subsequent leaks in these patients. Leak rates were 2·4 per cent overall (12 of 504), 2·6 per cent for colorectal anastomoses and 3 per cent for low anterior resection. When NIR-ICG imaging was used, the anastomotic leak rates were lower than those in the participating centres from over 1000 similar operations performed with identical technique but without NIR-ICG technology.

conclusionRoutine NIR-ICG assessment in patients undergoing elective colorectal surgery is feasible. NIR-ICG use may change intraoperative decisions, which may lead to a reduction in anastomotic leak rates.

Indexed as

ColectomyElective Surgical ProceduresProctectomySpectroscopy, Near-InfraredAdolescentAdultAgedAged, 80 and overAnastomosis, SurgicalAnastomotic LeakFemaleFluorescent DyesHumansIndocyanine GreenIntraoperative CareMaleFluorescent DyesIndocyanine Green

Identifiers

PMID29663330
PMCPMC6099466
OpenAlexW2810267871

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.