ArticleJournal of neuro-oncology2018
Individual changes in neurocognitive functioning and health-related quality of life in patients with brain oligometastases treated with stereotactic radiotherapy.
Article in Journal of neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- The Impact of Stereotactic or Whole Brain Radiotherapy on Neurocognitive Functioning in Adult Patients with Brain Metastases: A Systematic Review and Meta-Analysis.Oncology research and treatment · 2021Pooled it
- Health-related quality of life in adult patients with brain metastases after stereotactic radiosurgery: a systematic, narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Pooled it
- Challenges in interpreting individual-level changes in health-related quality of life in patients with glioma using minimally important differences (MIDs) and a 4-point Likert scale.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Trial
- The long-term course and relationship with survival of multidimensional fatigue in patients with brain metastases after Gamma Knife radiosurgery.Journal of cancer research and clinical oncology · 2023Trial
- Negative impact of hippocampal radiotherapy dose on memory function in patients with brain metastases.Neuro-oncology practice · 2026Article
- Individualized trajectories in postradiotherapy neurocognitive functioning of patients with brain metastases.Neuro-oncology practice · 2024Article
- Health-related quality of life after stereotactic radiosurgery in patients with brain metastases.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Evaluating patient reported outcomes and experiences in a novel proton beam clinic - challenges, activities, and outcomes of the ProtonCare project.BMC cancer · 2023Article
- Review
- Health-related quality of life after Gamma Knife radiosurgery in patients with 1-10 brain metastases.Journal of cancer research and clinical oncology · 2021Observational
- Measuring change in health-related quality of life: the impact of different analytical methods on the interpretation of treatment effects in glioma patients.Neuro-oncology practice · 2020Article
- Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo.Journal of neuroinflammation · 2020Article
- Prospective memory and brain metastases: a relevant target for rehabilitation in post-operative patients?Journal of neuro-oncology · 2020Article
- Article
- Cognitive functioning and predictors thereof in patients with 1-10 brain metastases selected for stereotactic radiosurgery.Journal of neuro-oncology · 2019Observational
- Multidimensional assessment of fatigue in patients with brain metastases before and after Gamma Knife radiosurgery.Journal of neuro-oncology · 2019Observational
- Health-related quality of life of patients with brain metastases selected for stereotactic radiosurgery.Journal of neuro-oncology · 2019Article
- Long-term survival results after treatment for oligometastatic brain disease.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, it has been shown that at group level, patients with limited brain metastases treated with stereotactic radiotherapy (SRT) maintain their pre-treatment levels of neurocognitive functioning (NCF) and health-related quality of life (HRQoL). The aim of this study was to evaluate NCF and HRQoL changes over time at the individual patient level.
methodsNCF (seven domains assessed with a standardized test battery) and HRQoL (eight predetermined scales assessed with the EORTC QLQ-C30 and BN20 questionnaires) were measured prior to SRT and at 3 and/or 6 months follow-up. Changes in NCF and HRQoL were evaluated at (1) a domain/scale level and (2) patient level.
resultsA total of 55 patients were examined, of which the majority showed stable NCF 3 months after SRT, on both the domain level (78-100% of patients) and patient level (67% of patients). This was different for HRQoL, where deterioration in the different scales was observed in 12-61% of patients, stable scores in 20-71%, and improvement in 16-40%, 3 months after SRT. At patient level, most patients (64%) showed both improvement and deterioration in different HRQoL scales. Results were similar between 3 and 6 months after SRT.
conclusionIn line with results at group level, most brain oligometastases patients with ≥ 6 months follow-up and treated with SRT maintained their pre-treatment level of NCF during this period. By contrast, changes in HRQoL scores differed considerably at domain and patient level, despite stable HRQoL scores at group level.
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