Evidence map›Paper›PMID 29663123›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2018

Creation of a restrictive atrial communication in heart failure with preserved and mid-range ejection fraction: effective palliation of left atrial hypertension and pulmonary congestion.

Anna Bauer, Markus Khalil, Monika Lüdemann, Jürgen Bauer, Anoosh Esmaeili, Roberta De-Rosa, Norbert F Voelkel, Hakan Akintuerk, Dietmar Schranz

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Anna BauerHessen Pediatric Heart Center, Justus Liebig University Clinic Giessen, Giessen, Germany.
Markus KhalilHessen Pediatric Heart Center, Justus Liebig University Clinic Giessen, Giessen, Germany.
Monika LüdemannHessen Pediatric Heart Center, Justus Liebig University Clinic Giessen, Giessen, Germany.
Jürgen BauerHessen Pediatric Heart Center, Justus Liebig University Clinic Giessen, Giessen, Germany.
Anoosh EsmaeiliHessen Pediatric Heart Center, Johann-Wolfgang Goethe University Hospital Frankfurt, Theodor-Storm-Kai. 7, 60590, Frankfurt, Germany.
Roberta De-RosaCardiovascular Department, University of Salerno, Fisciano, Italy.
Norbert F VoelkelFree University Medical Center (VUMC) Amsterdam, Amsterdam, The Netherlands.
Hakan AkintuerkHessen Pediatric Heart Center, Justus Liebig University Clinic Giessen, Giessen, Germany.
Dietmar SchranzHessen Pediatric Heart Center, Justus Liebig University Clinic Giessen, Giessen, Germany. dietmar.schranz@kgu.de.
University of Giessen · DEGoethe University Frankfurt · DEAmsterdam UMC Location VUmc · NLUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial decompression is considered in patients with symptomatic heart failure with preserved ejection fraction (HFpEF). We aimed to evaluate the feasibility and efficacy of transcatheter generation of a restrictive atrial septum communication to manage HFpEF from infancy to adulthood with cardiomyopathy and congenital heart defect. METHODS AND

resultsFrom June 2009 to December 2016, 24 patients (50% with an age less than 16 years) with HFpEF were palliated; NYHA-/Ross class IV (n = 10); median systemic ventricular ejection fraction 64 (range 35-78) %. Cardiomyopathy was classified as a restrictive (n = 4) or hypertrophic (n = 2). (75% related to congenital heart defects) Three patients had a systemic right ventricle; in the majority of patients, HFpEF was associated to complex congenital heart defects (n = 18). Mean pulmonary arterial pressures (PAP systolic/diastolic) were 56/28 (± 24/13), left atrial pressures (LAP, v-, a-wave, mean) 26/25/20 (± 7/10/6). Trans-septal puncture was used in 22 patients; foramen ovale dilatation in 2 patients. Median balloon size was 12 (range 6-18) mm; procedure time including diagnostic measures 125 (83-221) min. No procedural death or complications were observed. Mean LA-pressures decreased significantly to 19/19/15 ± 6/8/5 mmHg (p = 0.05); median brain natriuretic peptide (BNP) decreased from 392 (range 93-4401) pg/ml median BNP to 314 (range 61-1544) pg/ml (p = 0.05). Three patients died; one patient received orthotopic heart and one patient a heart-lung transplantation. No patient required so far an assist device. Clinical improvement occurred in all patients, in some after additional surgical or interventional approach.

conclusionsTranscatheter LA decompression is an age-independent, effective palliation treating patients with HFpEF.

Indexed as

AdolescentAdultAgedAtrial AppendageCardiac CatheterizationCardiac Surgical ProceduresChildChild, PreschoolDiastoleFemaleHeart FailureHeart VentriclesHumansHypertensionInfantMaleAtrial septostomy, restrictive atrial communicationDiastolic heart failurePreserved ejection fraction

Identifiers

PMID29663123
OpenAlexW2799797839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.