Evidence map›Paper›PMID 29662914›Full record

ArticleOrthopaedic journal of sports medicine2018

Ligament Strain Response Between Lower Extremity Contralateral Pairs During In Vitro Landing Simulation.

April L McPherson, Nathanial A Bates, Nathan D Schilaty, Christopher V Nagelli, Aaron J Krych, Timothy E Hewett

Abstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

April L McPhersonMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Nathanial A BatesDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Nathan D SchilatyDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Christopher V NagelliDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Aaron J KrychDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Timothy E HewettDepartment of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Funding

Musculoskeletal Research Training ProgramT32AR056950 · NIAMS · MAYO CLINIC ROCHESTER · PI Jennifer J Westendorf · 2009 to 2026
$7.0M
Mayo Clinic Interdisciplinary Women's Health Research ProgramK12HD065987 · NICHD · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2010 to 2023
$6.7M
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female AthletesR01AR055563 · NIAMS · OHIO STATE UNIVERSITY · PI BATES, NATHANIEL ANDREW, KRYCH, AARON · 2008 to 2022
$5.9M
Multi-faceted Approach to Modeling ACL Injury MechanismsR01AR056259 · NIAMS · OHIO STATE UNIVERSITY · PI HEWETT, TIMOTHY E · 2009 to 2017
$4.9M
NIAMS NIH HHS L30 AR070273NIAMS NIH HHS R01 AR055563NIAMS NIH HHS R01 AR056259NIAMS NIH HHS T32 AR056950NICHD NIH HHS K12 HD065987
6 · The paper itself

Abstract

backgroundLimb asymmetries, as determined through in vivo biomechanical measures, are known risk factors for anterior cruciate ligament (ACL) injury. Previous cadaveric studies have shown a lack of significant differences in ligament strain between contralateral lower extremities when identical kinematics were simulated on specimens. Recent methodological developments have applied in vivo knee kinetics to exert landing forces on cadaveric lower extremities to mimic ACL injury events, but it is unknown whether contralateral limbs fail in a consistent manner during impact simulator testing. HYPOTHESIS: It was hypothesized that contralateral lower extremities would not exhibit side-to-side differences in ligament strains. Furthermore, it was hypothesized that failure loads and failure locations would be independent of limb dominance. STUDY

designControlled laboratory study.

methodsFourteen pairs of cadaveric lower extremities were obtained from an anatomic donations program (8 female, 6 male; mean ± SD: age, 41.7 ± 8.1 years; mass, 86.8 ± 27.0 kg; body mass index, 29.4 ± 9.0 kg/m

resultsNo significant differences were observed in peak ACL or peak MCL strain for 5 loading conditions. Fisher exact tests of independence revealed that limb dominance was independent of both load at failure and failure location.

conclusionThere were no significant differences in ACL and MCL strain values between limb sides during in vitro impact simulation testing. This finding indicates that limb dominance does not influence the failure threshold of the ACL, since there was no significant difference in failure strains. The functional mechanics of the ACL are comparable between contralateral pairs from the same healthy specimen. CLINICAL RELEVANCE: Injury mechanisms and intra-articular mechanics cannot be ethically studied in an in vivo setting. The current study provides additional insight into limb asymmetry that is observed among athletes in clinical sports medicine settings.

Indexed as

anterior cruciate ligamentcontralateral pairsinjury simulationknee ligament biomechanics

Identifiers

PMID29662914
PMCPMC5894909

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.