ArticleLiver cancer2018
Short-Term Outcomes following Hepatectomy in Elderly Patients with Hepatocellular Carcinoma: An Analysis of 10,805 Septuagenarians and 2,381 Octo- and Nonagenarians in Japan.
Article in Liver cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Volume-outcome relationship in anatomical and non-anatomical liver resections: a rapid systematic review.BMC gastroenterology · 2026Pooled it
- Trial
- Prognostic impact of malnutrition based on the global leadership initiative on malnutrition criteria in older patients undergoing liver resection for hepatocellular carcinoma.Surgery today · 2026Article
- Preoperative Albumin-Bilirubin Score as a Predictor of Postoperative Complications After Liver Resection.Cureus · 2026Article
- Developing a Novel Artificial Intelligence Framework to Measure the Balance of Clinical Versus Nonclinical Influences on Posthepatectomy Length of Stay.Annals of surgical oncology · 2025Article
- A Composite Endpoint of Liver Surgery (CELS): Development and Validation of a Clinically Relevant Endpoint Requiring a Smaller Sample Size.Annals of surgical oncology · 2025Article
- Delayed Return of Gastrointestinal Function after Partial Hepatectomy: A Single-Center Cross-Sectional Study.Digestive surgery · 2025Article
- Efficacy and safety of high-intensity focused ultrasound ablation under general anesthesia in older hepatocellular carcinoma patients.Frontiers in oncology · 2025Article
- A Decade of Experience Between Open and Minimally Invasive Hepatectomies for Hepatocellular Carcinoma.Medicina (Kaunas, Lithuania) · 2024Article
- Observational
- Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study.Langenbeck's archives of surgery · 2024Observational
- Efficacy and safety of terlipressin infusion during liver surgery: a protocol for systematic review and meta-analysis.BMJ open · 2024Article
- Radiofrequency for hepatocellular carcinoma larger than 3 cm: potential for applications in daily practice.Journal of liver cancer · 2024Article
- Peri-operative score for elderly patients with resectable hepatocellular carcinoma.World journal of hepatology · 2023Article
- Is Lymphadenectomy Reasonable for Elderly Intrahepatic Cholangiocarcinoma Patients?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Article
- The Hong Kong consensus statements on unresectable hepatocellular carcinoma: narrative review and update for 2021.Hepatobiliary surgery and nutrition · 2023Review
- Oncologic Liver Resections in a Geriatric Population: Peri-operative, Long-Term and Quality-of-Life Outcomes-Experience from a High-Volume Centre in India.World journal of surgery · 2023Article
- Liver resection versus radiofrequency ablation in octogenarian patients for hepatocellular carcinoma: a propensity score multicenter analysis.Surgical endoscopy · 2023Article
- Efficacy and Safety of Liver Resection in Super Elderly Patients with Hepatocellular Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs the population is aging, the indication for hepatocellular carcinoma (HCC) resection in patients aged over 80 years will increase. Japan is facing the most aging society worldwide. We examined the safety of hepatectomy in octogenarians and nonagenarians using large-scale data from the Diagnosis Procedure Combination database, a national administrative database in Japan.
methodWe conducted a survey to collect data for all inpatients from 2007 and 2012. We identified 27,094 patients who underwent hepatectomy for HCC. Patients' age was divided into the following five categories: ≤59, 60-69, 70-79, 80-84, and ≥85 years (
resultsThe mortality and morbidity rates were 2.6 and 23.4%, respectively. Compared with patients in their 70s, the mortality rate was significantly lower in patients aged ≤59 years (odds ratio [OR], 0.34; 95% confidence interval [CI], 0.26-0.45;
conclusionsThe operative risk for hepatectomy gradually increases with age until patients are in their 70s, and it appears to reach a plateau among septuagenarian. Indeed, age over 70 years can also be a risk factor for HCC. By considering the aging risk, surgeons can attain good outcome after hepatectomy even in octo- and nonagenarian patients.
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