ArticleJournal of orthopaedic translation2018
Three-dimensional morphometric properties of rod- and plate-like trabeculae in adolescent cancellous bone.
Article in Journal of orthopaedic translation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Divergent trajectories of structural accrual and matrix-level mechanical properties during alveolar bone maturation.Calcified tissue international · 2026Article
- Assessment of Vertebral Body Bone Quality in Adolescent Idiopathic Scoliosis (AIS) Using Micro-CT, qBEI, and Nanoindentation-A Case Study.JOR spine · 2026Article
- Stochastic parametric skeletal dosimetry model for humans: Anatomical-morphological basis and parameter evaluation.PloS one · 2025Article
- Additive Manufacturing of Biomaterials-Design Principles and Their Implementation.Materials (Basel, Switzerland) · 2022Review
- 3-D microarchitectural properties and rod- and plate-like trabecular morphometric properties of femur head cancellous bones in patients with rheumatoid arthritis, osteoarthritis, and osteoporosis.Journal of orthopaedic translation · 2021Article
- Impaired bone microarchitecture in distal interphalangeal joints in patients with primary hypertrophic osteoarthropathy assessed by high-resolution peripheral quantitative computed tomography.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Clinical translation and application in orthopaedics.Journal of orthopaedic translation · 2018Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveDespite many researches have been carried out on the three-dimensional microarchitecture of cancellous bone, the morphometric properties of rod and plate trabeculae in adolescent cancellous bone have not yet been investigated. This study aimed to investigate three-dimensional morphometric properties of rod- and plate-like trabeculae in normal adolescent cancellous bone, and to compare them with adult cancellous bones to reveal morphometric changes from adolescence to adult life to obtain more insight into the subchondral bone adaptations during development and growth.
methodsThis study included 23 normal human proximal tibiae. These tibiae were divided into three groups: adolescents (9-17 years, n = 6), young adults (18-24 years, n = 9), and adults (25-30 years, n = 8). From each tibia, six cubic cancellous bone samples (dimensions 8 × 8 × 8 mm
resultsSignificant differences in some morphometric parameters were revealed. The mean longitudinal length of rods was significantly greater in the adolescents than in the young adults. Plate volume density showed an increasing trend with age, although not significant. Trabeculae were more plate-like in adolescents in the medial condyle of adolescents than in the lateral condyle, and changed towards more plate-like trabeculae in the adults. The single best predictor for the mechanical properties was apparent density. Apparent density alone explained 59% variations in Young's modulus, 77% in ultimate stress and 34% in failure energy, respectively (all p < 0.01). Morphometric parameters might improve this prediction.
conclusionIn conclusion, this study has reported for the first time the morphometric parameters of rod- and plate-like trabeculae in adolescent proximal tibial cancellous bone, which will improve our understanding of morphometric changes in individual trabeculae during development and growth. Furthermore, separate analysis of individual rods and plates may also help reveal disease-related morphometric changes beyond bone mineral density. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: A thorough quantification of individual trabeculae during development and growth may help understand disease-related 3-D morphometric changes beyond bone mineral density.
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