Evidence map›Paper›PMID 29662757›Full record

ReviewJournal of orthopaedic translation2017

Bedside to bench and back to bedside: Translational implications of targeted intervertebral disc therapeutics.

Gary Joel Rosenberg, Albert J M Yee, W Mark Erwin

Open access · goldAbstract readReview
In one paragraph

Review in Journal of orthopaedic translation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Gary Joel RosenbergSunnybrook Health Sciences Centre, Holland Musculoskeletal Program, Division of Orthopaedic Surgery, Toronto, ON, Canada.
Albert J M YeeSunnybrook Health Sciences Centre, Holland Musculoskeletal Program, Division of Orthopaedic Surgery, Toronto, ON, Canada.
W Mark ErwinDivisions of Neurological and Orthopaedic Surgery, University of Toronto, Toronto, ON, Canada.
Sunnybrook Health Science Centre · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal pain and associated disability is a leading cause of morbidity worldwide that has a strong association with degenerative disc disease (DDD). DDD can begin in early-late adolescence and has a variable course. Biologically based therapies to treat DDD face significant challenges posed by the unique milieu of the environment within the intervertebral discs. Many potential promising therapies are still in the early stages of development with a hostile microenvironment within the disc presenting unique challenges.

Indexed as

back paindisc injectionsintervertebral disc diseasestem cell treatment

Identifiers

PMID29662757
PMCPMC5822961
OpenAlexW2606063869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.