Evidence map›Paper›PMID 29662617›Full record

ArticleOncotarget2018

Premature ovarian aging in

Irit Ben-Aharon, Mattan Levi, David Margel, Rinat Yerushalmi, Shulamith Rizel, Shlomit Perry, Eran Sharon, Noa Hasky, Ronit Abir, Benny Fisch and 3 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Association of Germline BRCA Pathogenic Variants With Diminished Ovarian Reserve: A Meta-Analysis of Individual Patient-Level Data.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Pooled it
  3. Article
  4. Review
  5. Review
  6. Observational
  7. Susceptibility of Brca1Cancer science · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. BRCA, infertility, and fertility preservation: a review for counseling.Journal of assisted reproduction and genetics · 2023
    Review
  12. The Impact of BRCA1- and BRCA2 Mutations on Ovarian Reserve Status.Reproductive sciences (Thousand Oaks, Calif.) · 2023
    Article
  13. Bone health after RRBSO amongJournal of gynecologic oncology · 2022
    Article
  14. Breaking the aging epigenetic barrier.Frontiers in cell and developmental biology · 2022
    Review
  15. Irinotecan (CPT-11) Treatment Induces Mild Gonadotoxicity.Frontiers in reproductive health · 2022
    Article
  16. Article
  17. Splicing alterations in healthy aging and disease.Wiley interdisciplinary reviews. RNA · 2021
    Review
  18. The Emerging Key Role of Klotho in the Hypothalamus-Pituitary-Ovarian Axis.Reproductive sciences (Thousand Oaks, Calif.) · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Irit Ben-Aharon *Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Mattan Levi *Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel.
David MargelInstitute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Rinat YerushalmiInstitute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Shulamith RizelInstitute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Shlomit PerryInstitute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Eran SharonDepartment of Surgery, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Noa HaskyDepartment of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel.
Ronit AbirIVF and Infertility Unit, Schneider Women Hospital, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Benny FischIVF and Infertility Unit, Schneider Women Hospital, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Ana TobarDepartment of Pathology, Rabin Medical Center, Petach Tikva, Israel.
Ruth ShalgiDepartment of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Tel-Aviv, Israel.
Salomon Marcello StemmerInstitute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel.
Tel Aviv University · ILRabin Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThough former evidence implies a correlation of breast cancer susceptibility gene ( EXPERIMENTAL

designHealthy female

resultsThirty-three female (median age 35y) and 20 male (44y)

conclusionsOur results suggest a link between

Indexed as

BRCAovarian agingsystemic precocious aging

Identifiers

PMID29662617
PMCPMC5882308
OpenAlexW2792743059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.