ArticleClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology2018
Thyroid hormone status in patients with severe selenium deficiency.
Article in Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Recent advances of trace elements in autoimmune thyroid disease.Frontiers in immunology · 2025Review
- Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc.Hormones (Athens, Greece) · 2024Article
- SUBCLINICAL HYPOTHYROIDISM PREVALENCE AND SELENIUM LEVELS IN WOMEN OF NORTH KHORASAN, IRAN: A CROSS-SECTIONAL STUDY.Acta clinica Croatica · 2024Article
- Low urinary selenium levels are associated with iodine deficiency in Brazilian schoolchildren and adolescents.Endocrine · 2021Article
- Role of Selenium Deficiency in Pediatrics with Acquired Hypothyroidism.International journal of preventive medicine · 2021Article
- Thyroid function in patients with selenium deficiency exhibits high free T4 to T3 ratio.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2021Article
- Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.Scientific reports · 2018Article
- Selenium and Selenoproteins in Immune Mediated Thyroid Disorders.Diagnostics (Basel, Switzerland) · 2018Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selenium (Se) is an essential trace element that is involved in numerous biological processes in the form of a selenoprotein such as iodothyronine deiodinase (DIO). Se deficiency may prevent the conversion of T4 to T3 through reducing DIO expression and thereby affecting thyroid hormone status. However, this has not been well documented in humans. In this study, to clarify the association between Se and thyroid hormone status, we investigated the thyroid hormone levels in patients with severe Se deficiency (< 2 µg/dl). Severe Se deficiency was associated with increases in free T4 levels, but not with decreases and increases in free T3 and thyroid stimulating hormone (TSH) levels, respectively. Increases in free T4 levels during Se deficiency were reduced with Se supplementation; however, neither free T3 nor TSH levels were affected. Taken together, these findings indicate that free T4 may be a useful biomarker for Se status when serum Se levels are severely low.
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