Evidence map›Paper›PMID 29662216›Full record

ArticleNature neuroscience2018

Cortical drive and thalamic feed-forward inhibition control thalamic output synchrony during absence seizures.

Cian McCafferty, François David, Marcello Venzi, Magor L Lőrincz, Francis Delicata, Zoe Atherton, Gregorio Recchia, Gergely Orban, Régis C Lambert, Giuseppe Di Giovanni and 2 more

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 131 citations in OpenAlex.

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  13. Interruption of rat absence seizures by auditory stimulation.bioRxiv : the preprint server for biology · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Cian McCaffertyNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK. mccaffertycp@cardiff.ac.uk.ORCID 0000-0001-5206-4450
François DavidNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.ORCID 0000-0003-1993-8931
Marcello VenziNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.
Magor L LőrinczDepartment of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
Francis DelicataNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.
Zoe AthertonNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.
Gregorio RecchiaNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.ORCID 0000-0003-4836-1529
Gergely OrbanNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.ORCID 0000-0003-4222-9391
Régis C LambertSorbonne Université, CNRS, Inserm, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris, France.
Giuseppe Di GiovanniNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK.
Nathalie LerescheSorbonne Université, CNRS, Inserm, Neuroscience Paris Seine - Institut de Biologie Paris Seine (NPS - IBPS), Paris, France.
Vincenzo CrunelliNeuroscience Division, School of Bioscience, Cardiff University, Cardiff, UK. crunelli@cardiff.ac.uk.ORCID 0000-0001-7154-9752
University of Malta · MTCardiff University · GBCentre National de la Recherche Scientifique · FRUniversité Claude Bernard Lyon 1 · FRUniversity of Szeged · HUYale University · US

Funding

Medical Research Council G0900671Wellcome Trust 091882
6 · The paper itself

Abstract

Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca

Indexed as

Action PotentialsAnimalsCalcium Channels, T-TypeCerebral CortexComputer SimulationElectroencephalographyFeedback, PhysiologicalMaleNeural PathwaysNeuronsRatsRats, WistarRecruitment, NeurophysiologicalSeizuresThalamusCalcium Channels, T-Type

Identifiers

PMID29662216
PMCPMC6278913
OpenAlexW2797102036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.