ArticleNature neuroscience2018
Locomotor activity modulates associative learning in mouse cerebellum.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed.
- The Effect of Integrated Aerobic and Cognitive Training (Activ4Brain) on Cognition and Neurophysiology in Older Adults: Protocol for a Controlled Trial.JMIR research protocols · 2026Article
- Neural circuits encode prior knowledge of temporal statistics.Nature neuroscience · 2026Article
- Article
- Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior.Nature communications · 2026Article
- Visual learning performance in free-flying honey bees is independent of sucrose and light responsiveness and depends on training context.Scientific reports · 2026Article
- Contextual effects during sensorimotor adaptation are an emergent property of population coding in a cerebellar-inspired model.Science advances · 2025Article
- Stimulus Contingency and Task Context Encoding within the Anterior Cingulate-Amygdala-Cerebellum Associative Learning Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Processing reliant on granule cells is essential for motor learning but dispensable for social preference and numerous other cerebellar-dependent behaviors.Nature communications · 2025Article
- Climbing fibers selectively recruit disinhibitory interneurons to enhance dendritic calcium signaling in cerebellar Purkinje cells.bioRxiv : the preprint server for biology · 2025Article
- Fast implicit and slow explicit learning of temporal context.Scientific reports · 2025Article
- Neuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.Nature communications · 2025Article
- Article
- A cerebellar granule cell-climbing fiber computation to learn to track long time intervals.Neuron · 2024Article
- Climbing fibers provide essential instructive signals for associative learning.Nature neuroscience · 2024Article
- A cerebellar population coding model for sensorimotor learning.bioRxiv : the preprint server for biology · 2024Article
- Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.Nature neuroscience · 2024Article
- Acute aerobic exercise enhances associative learning in regular exercisers but not in non-regular exercisers.Frontiers in behavioral neuroscience · 2024Article
- Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models.Cell reports · 2023Article
- Accessible and reliable neurometric testing in humans using a smartphone platform.Scientific reports · 2023Article
- Synaptic mechanisms for associative learning in the cerebellar nuclei.Nature communications · 2023Article
9 more citing papers are in PubMed but not listed here.
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4 authors.
Funding
Abstract
Changes in behavioral state can profoundly influence brain function. Here we show that behavioral state modulates performance in delay eyeblink conditioning, a cerebellum-dependent form of associative learning. Increased locomotor speed in head-fixed mice drove earlier onset of learning and trial-by-trial enhancement of learned responses that were dissociable from changes in arousal and independent of sensory modality. Eyelid responses evoked by optogenetic stimulation of mossy fiber inputs to the cerebellum, but not at sites downstream, were positively modulated by ongoing locomotion. Substituting prolonged, low-intensity optogenetic mossy fiber stimulation for locomotion was sufficient to enhance conditioned responses. Our results suggest that locomotor activity modulates delay eyeblink conditioning through increased activation of the mossy fiber pathway within the cerebellum. Taken together, these results provide evidence for a novel role for behavioral state modulation in associative learning and suggest a potential mechanism through which engaging in movement can improve an individual's ability to learn.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.