ArticleNature neuroscience2018
Encoding of error and learning to correct that error by the Purkinje cells of the cerebellum.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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Who cites it
115 citing papers in PubMed.
- Head impulse compensatory saccades: Visual dependence is most evident in bilateral vestibular loss.PloS one · 2020Trial
- Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar rhythms: mechanisms, functions and translational opportunities.Nature reviews. Neuroscience · 2026Review
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- Actions as perceptual experiments.Journal of vision · 2026Review
- Article
- Anodal high-definition transcranial direct current stimulation reveals a specific role for posterior parietal cortex in interlimb generalization.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Visuomotor training induces network reorganisation of frontal eye field and cuneus connectivity: A task-based fMRI study.Neuroimage. Reports · 2026Article
- A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells.Journal of neurophysiology · 2026Review
- Consensus Paper: Models of Cerebellar Functions.Cerebellum (London, England) · 2026Review
- Article
- Rapid motor skill adjustment is associated with population-level modulation of cerebellar error signals.Nature neuroscience · 2026Article
- A transient feature of the inferior olive supports the development of cerebellar internal models.bioRxiv : the preprint server for biology · 2025Article
- Serial dependencies and overt attention shifts.Journal of vision · 2025Article
- Concurrent Bilateral M1 and Anodal Cerebellar tDCS Effects on Learning of a Bimanual Video Game Task.Brain and behavior · 2025Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
- Contextual effects during sensorimotor adaptation are an emergent property of population coding in a cerebellar-inspired model.Science advances · 2025Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- Whole Body Motor Adaptation in Goldfish Using Fish Operated Vehicle.The European journal of neuroscience · 2025Article
- Protection of savings by reducing the salience of opposing errors.NPJ science of learning · 2025Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
The primary output cells of the cerebellar cortex, Purkinje cells, make kinematic predictions about ongoing movements via high-frequency simple spikes, but receive sensory error information about that movement via low-frequency complex spikes (CS). How is the vector space of sensory errors encoded by this low-frequency signal? Here we measured Purkinje cell activity in the oculomotor vermis of animals during saccades, then followed the chain of events from experience of visual error, generation of CS, modulation of simple spikes, and ultimately change in motor output. We found that while error direction affected the probability of CS, error magnitude altered its temporal distribution. Production of CS changed the simple spikes on the next trial, but regardless of the actual visual error, this change biased the movement only along a vector that was parallel to the Purkinje cell's preferred error. From these results, we inferred the anatomy of a sensory-to-motor adaptive controller that transformed visual error vectors into motor-corrections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.