ArticleNature immunology2018
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4
Erratum issuedAbstract read
In one paragraph
Article in Nature immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 101 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 152 citations in OpenAlex.
- GWAS-Identified Variants for Obesity Do Not Influence the Risk of Developing Multiple Myeloma: A Population-Based Study and Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro.Cellular & molecular immunology · 2026Article
- Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells.Science advances · 2026Article
- LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype.JCI insight · 2026Article
- Inhibition of LARP4-mediated quiescence exit of naive CD4Nature biomedical engineering · 2026Article
- Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.Addiction (Abingdon, England) · 2026Article
- REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis.The Journal of experimental medicine · 2026Article
- Extracellular vesicles from glycolytic mesenchymal stromal cells restrain arthritis progression via IL-10-Producing T and B cells.Theranostics · 2026Article
- Metabolic regulation of T cell production of IL-10 and IL-22 protects against intestinal inflammation.Precision clinical medicine · 2025Article
- BayesCNet: Bayesian inference for cell type-specific regulatory networks leveraging cell type hierarchy in single-cell data.bioRxiv : the preprint server for biology · 2025Article
- Aberrant T follicular helper cells generated by TNature immunology · 2025Article
- Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation.Nature immunology · 2025Article
- Transcription Factor Blimp-1: A Central Regulator of Oxidative Stress and Metabolic Reprogramming in Chronic Inflammatory Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Transcription factor c-Maf: a checkpoint that programs autoimmunity.Frontiers in immunology · 2025Review
- Article
- Indoleamine 2,3-dioxygenase-galectin-3 fusion protein remodels inflammatory and fibrotic programs, ameliorating imiquimod-induced psoriasis.npj biomedical innovations · 2025Article
- Interleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets.iScience · 2024Article
- Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes.Nature communications · 2024Article
- Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion.Nature communications · 2024Article
- Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byc-Maf in CD42018
- Erratum issued
Authors and funding
21 authors at 4 institutions in 3 countries.
Leona GabryšováThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.ORCID http://orcid.org/0000-0003-3529-1306
Marisol Alvarez-MartinezThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.
Raphaëlle LuisierThe Francis Crick Institute, Computational Biology Laboratory, London, UK.ORCID http://orcid.org/0000-0002-4860-5776
Luke S CoxThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.ORCID http://orcid.org/0000-0002-5477-8622
Jan SodenkampThe Francis Crick Institute, Malaria Laboratory, London, UK.
Caroline HoskingThe Francis Crick Institute, Malaria Laboratory, London, UK.
Damián Pérez-MazliahThe Francis Crick Institute, Malaria Laboratory, London, UK.
Charlotte WhicherThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.
Yashaswini KannanThe Francis Crick Institute, Helminth Immunology Laboratory, London, UK.
Krzysztof PotempaThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.
Xuemei WuThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK.
Leena BhawThe Francis Crick Institute, Advanced Sequencing Facility Laboratory, London, UK.
Hagen WendeHeidelberg University, Institute of Pharmacology, Heidelberg, Germany.
Michael H SiewekeAix Marseille University, CNRS, INSERM, CIML, Marseille, France.
Greg ElgarThe Francis Crick Institute, Advanced Sequencing Facility Laboratory, London, UK.
Mark WilsonThe Francis Crick Institute, Helminth Immunology Laboratory, London, UK.
James BriscoeThe Francis Crick Institute, Developmental Dynamics Laboratory, London, UK.ORCID http://orcid.org/0000-0002-1020-5240
Vicki MetzisThe Francis Crick Institute, Developmental Dynamics Laboratory, London, UK.ORCID http://orcid.org/0000-0002-0399-1722
Jean LanghorneThe Francis Crick Institute, Malaria Laboratory, London, UK.
Nicholas M LuscombeThe Francis Crick Institute, Computational Biology Laboratory, London, UK.ORCID http://orcid.org/0000-0001-5293-4778
Anne O'GarraThe Francis Crick Institute, Laboratory of Immunoregulation and Infection, London, UK. anne.ogarra@crick.ac.uk.ORCID http://orcid.org/0000-0001-9845-6134
The Francis Crick Institute · GBCentre National de la Recherche Scientifique · FRHeidelberg University · DEImperial College London · GB
Funding
Cancer Research UK FC001126Cancer Research UK FC001220European Research Council 294682Medical Research Council FC001101Medical Research Council FC001110Medical Research Council FC001999Medical Research Council MC_U117565642Medical Research Council MR/L016311/1Wellcome Trust FC001051Wellcome Trust FC001126
Abstract
The transcription factor c-Maf induces the anti-inflammatory cytokine IL-10 in CD4
Indexed as
AnimalsCD4-Positive T-LymphocytesGene Expression RegulationGene Regulatory NetworksInterleukin-2MiceProto-Oncogene Proteins c-mafInterleukin-2Maf protein, mouseProto-Oncogene Proteins c-maf
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.