ArticleNature microbiology2018
The extracellular domain of Staphylococcus aureus LtaS binds insulin and induces insulin resistance during infection.
Article in Nature microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
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- Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice.Molecular metabolism · 2024Article
- The Acari Hypothesis, VI: human sebum and the cutaneous microbiome in allergy and in lipid homeostasis.Frontiers in allergy · 2024Article
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- Mediation Analysis of Waist Circumference in the Association of Gut Microbiota with Insulin Resistance in Children.Children (Basel, Switzerland) · 2023Article
- Regulation of the immune system by the insulin receptor in health and disease.Frontiers in endocrinology · 2023Review
- Physicochemical Properties of the Soluble Dietary Fiber fromNutrients · 2022Article
- Which Role Plays 2-Hydroxybutyric Acid on Insulin Resistance?Metabolites · 2021Review
- Monoclonal Antibodies Targeting Surface-Exposed and Secreted Proteins from Staphylococci.Vaccines · 2021Review
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- New model in diabetic mice to evaluate the effects of insulin therapy on biofilm development in wounds.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2020Article
- Natural Selection, The Microbiome, and Public Health.The Yale journal of biology and medicine · 2018Review
- Cytokine and Adhesion Molecule Expression Induced by Different Strains ofFrontiers in immunology · 2018Article
- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity.Frontiers in pediatrics · 2018Review
- Serum Irisin: A Potential Diagnostic Marker for Insulin Resistance in Acne Vulgaris.Indian journal of dermatologyArticle
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance is a risk factor for obesity and diabetes and predisposes individuals to Staphylococcus aureus colonization; however, the contribution of S. aureus to insulin resistance remains unclear. Here, we show that S. aureus infection causes impaired glucose tolerance via secretion of an insulin-binding protein extracellular domain of LtaS, eLtaS, which blocks insulin-mediated glucose uptake. Notably, eLtaS transgenic mice (eLtaS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.