Evidence map›Paper›PMID 29662019›Full record

ReviewMolecules (Basel, Switzerland)2018

Liposomal Drug Delivery Systems and Anticancer Drugs.

Temidayo O B Olusanya, Rita Rushdi Haj Ahmad, Daniel M Ibegbu, James R Smith, Amal Ali Elkordy

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 4 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 4 syntheses or guidelines pooled it, 585 citations in OpenAlex.

  1. Liposomal delivery of gene therapy for ovarian cancer: a systematic review.Reproductive biology and endocrinology : RB&E · 2023
    Pooled it
  2. Pooled it
  3. Pooled it
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  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Polymerization from Lipid Membranes.Biomacromolecules · 2026
    Article
  11. Review
  12. Article
  13. Article
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  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article

130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Temidayo O B OlusanyaSchool of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UK. Temidayo.olusanya@sunderland.ac.uk.ORCID 0000-0002-3565-2442
Rita Rushdi Haj AhmadSchool of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UK. ritahajahmad@yahoo.co.uk.
Daniel M IbegbuDepartment of Medical Biochemistry, College of Medicine, University of Nigeria Enugu Campus, Nigeria. daniel.ibegbu@unn.edu.ng.
James R SmithSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK. james.smith@port.ac.uk.
Amal Ali ElkordySchool of Pharmacy and Pharmaceutical Sciences, University of Sunderland, Sunderland SR1 3SD, UK. amal.elkordy@sunderland.ac.uk.ORCID 0000-0002-0781-1127
University of Sunderland · GBUniversity of Nigeria · NGUniversity of Portsmouth · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a life-threatening disease contributing to ~3.4 million deaths worldwide. There are various causes of cancer, such as smoking, being overweight or obese, intake of processed meat, radiation, family history, stress, environmental factors, and chance. The first-line treatment of cancer is the surgical removal of solid tumours, radiation therapy, and chemotherapy. The systemic administration of the free drug is considered to be the main clinical failure of chemotherapy in cancer treatment, as limited drug concentration reaches the tumour site. Most of the active pharmaceutical ingredients (APIs) used in chemotherapy are highly cytotoxic to both cancer and normal cells. Accordingly, targeting the tumour vasculatures is essential for tumour treatment. In this context, encapsulation of anti-cancer drugs within the liposomal system offers secure platforms for the targeted delivery of anti-cancer drugs for the treatment of cancer. This, in turn, can be helpful for reducing the cytotoxic side effects of anti-cancer drugs on normal cells. This short-review focuses on the use of liposomes in anti-cancer drug delivery.

Indexed as

Drug Delivery SystemsAnimalsAntineoplastic AgentsDrug CompoundingHumansLiposomesNeoplasmsAntineoplastic AgentsLiposomesanticancer drugsdrug deliveryliposomes

Identifiers

PMID29662019
PMCPMC6017847
OpenAlexW2797455782

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.