ArticleMaterials (Basel, Switzerland)2018
Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-Based Injectable Bone Substitutes.
Article in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Enhanced Osteoinduction, Rheological and Mechanical Performance of 3D-Printed Methylcellulose-Gelatin-Hydroxyapatite Scaffolds.Journal of functional biomaterials · 2026Article
- Hyaluronan-Containing Injectable Magnesium-Calcium Phosphate Cements Demonstrated Improved Performance, Cytocompatibility, and Ability to Support Osteogenic Differentiation In Vitro.International journal of molecular sciences · 2025Article
- Two decades of continuous progresses and breakthroughs in the field of bioactive ceramics and glasses driven by CICECO-hub scientists.Bioactive materials · 2024Review
- XGB Modeling Reveals Improvement of Compressive Strength of Cement-Based Composites with Addition of HPMC and Chitosan.Materials (Basel, Switzerland) · 2024Article
- Synthetic Calcium-Phosphate Materials for Bone Grafting.Polymers · 2023Review
- Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity.Gels (Basel, Switzerland) · 2023Review
- Injectable bone cements: What benefits the combination of calcium phosphates and bioactive glasses could bring?Bioactive materials · 2023Review
- Polymeric Nanocomposites for Environmental and Industrial Applications.International journal of molecular sciences · 2022Review
- Bioactive Hydrogels: Design and Characterization of Cellulose-Derived Injectable Composites.Materials (Basel, Switzerland) · 2021Article
- An In Situ Gelling System for the Local Treatment of Inflammatory Bowel Disease (IBD). The Loading of Maqui (Pharmaceutics · 2019Article
- Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application.Molecules (Basel, Switzerland) · 2019Review
- Special Issue: Novel Advances and Approaches in Biomedical Materials Based on Calcium Phosphates.Materials (Basel, Switzerland) · 2019Article
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Authors and funding
2 authors.
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Abstract
In this study, a novel injectable bone substitute (IBS) was prepared by incorporating a bioceramic powder in a polymeric solution comprising of methylcellulose (MC), gelatin and citric acid. Methylcellulose was utilized as the polymeric matrix due to its thermoresponsive properties and biocompatibility. 2.5 wt % gelatin and 3 wt % citric acid were added to the MC to adjust the rheological properties of the prepared IBS. Then, 0, 20, 30 and 50 wt % of the bioceramic component comprising tetracalcium phosphate/hydroxyapatite (TTCP/HA), dicalcium phosphate dehydrate (DCPD) and calcium sulfate dehydrate (CSD) were added into the prepared polymeric component. The prepared IBS samples had a chewing gum-like consistency. IBS samples were investigated in terms of their chemical structure, rheological characteristics, and mechanical properties. After that, in vitro degradation studies were carried out by measurement of pH and % remaining weight. Viscoelastic characteristics of the samples indicated that all of the prepared IBS were injectable and they hardened at approximately 37 °C. Moreover, with increasing wt % of the bioceramic component, the degradation rate of the samples significantly reduced and the mechanical properties were improved. Therefore, the experimental results indicated that the P50 mix may be a promising candidates to fill bone defects and assist bone recovery for non-load bearing applications.
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