ArticleBrain sciences2018
The Effect of Axon Resealing on Retrograde Neuronal Death after Spinal Cord Injury in Lamprey.
Article in Brain sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Spinal cord injury significantly alters the properties of reticulospinal neurons: delayed repolarization mediated by potassium channels.Journal of neurophysiology · 2023Article
- Article
- The Composition and Cellular Sources of CSPGs in the Glial Scar After Spinal Cord Injury in the Lamprey.Frontiers in molecular neuroscience · 2022Article
- Source of Early Regenerating Axons in Lamprey Spinal Cord Revealed by Wholemount Optical Clearing with BABB.Cells · 2020Article
- Heterogeneity in the regenerative abilities of central nervous system axons within species: why do some neurons regenerate better than others?Neural regeneration research · 2020Review
- Mechanisms of Axon Elongation Following CNS Injury: What Is Happening at the Axon Tip?Frontiers in cellular neuroscience · 2020Article
- Activated Erk Is an Early Retrograde Signal After Spinal Cord Injury in the Lamprey.Frontiers in neuroscience · 2020Article
- Role of axon resealing in retrograde neuronal death and regeneration after spinal cord injury.Neural regeneration research · 2019Review
- Bridging the gap: Spinal cord fusion as a treatment of chronic spinal cord injury.Surgical neurology international · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Failure of axon regeneration in the central nervous system (CNS) of mammals is due to both extrinsic inhibitory factors and to neuron-intrinsic factors. The importance of intrinsic factors is illustrated in the sea lamprey by the 18 pairs of large, individually identified reticulospinal (RS) neurons, whose axons are located in the same spinal cord tracts but vary greatly in their ability to regenerate after spinal cord transection (TX). The neurons that are bad regenerators also undergo very delayed apoptosis, signaled early by activation of caspases. We noticed that the neurons with a low probability of axon regeneration tend to be larger than the good regenerators. We postulate that the poorly regenerating larger neurons have larger caliber axons, which reseal more slowly, allowing more prolonged entry of toxic signals (e.g., Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.