ArticleAging2018
The evolution of CpG density and lifespan in conserved primate and mammalian promoters.
Article in Aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Review
- Epigenetic Potential and Dispersal Propensity in a Free-Living Songbird: A Spatial and Temporal Approach.Molecular ecology · 2025Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
- Fish species lifespan prediction from promoter cytosine-phosphate-guanine density.Molecular ecology resources · 2025Article
- De novo whole-genome assembly of the critically endangered southern muriqui (Brachyteles arachnoides).G3 (Bethesda, Md.) · 2025Article
- Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds.Advanced biology · 2025Article
- Epigenetic clocks and programmatic aging.Ageing research reviews · 2024Review
- Universal prediction of vertebrate species age at maturity.Communications biology · 2024Article
- Liver epigenomic signature associated with chronic oxidative stress in a mouse model of glutathione deficiency.Chemico-biological interactions · 2024Article
- A genomic predictor for age at sexual maturity for mammalian species.Evolutionary applications · 2024Article
- The rate of epigenetic drift scales with maximum lifespan across mammals.Nature communications · 2023Article
- Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases.Progress in brain research · 2023Article
- Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids.Communications biology · 2021Article
- The mitochondrial genome and Epigenome of the Golden lion Tamarin from fecal DNA using Nanopore adaptive sequencing.BMC genomics · 2021Article
- DNA methylation predicts age and provides insight into exceptional longevity of bats.Nature communications · 2021Article
- Footprints in the Sand: Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity.Frontiers in genetics · 2021Review
- Diversification of CpG-Island Promoters Revealed by Comparative Analysis Between Human and Rhesus Monkey Genomes.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Article
- Article
- The role of environmental exposures and the epigenome in health and disease.Environmental and molecular mutagenesis · 2020Review
- A genomic predictor of lifespan in vertebrates.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Gene promoters are evolutionarily conserved across holozoans and enriched in CpG sites, the target for DNA methylation. As animals age, the epigenetic pattern of DNA methylation degrades, with highly methylated CpG sites gradually becoming demethylated while CpG islands increase in methylation. Across vertebrates, aging is a trait that varies among species. We used this variation to determine whether promoter CpG density correlates with species' maximum lifespan. Human promoter sequences were used to identify conserved regions in 131 mammals and a subset of 28 primate genomes. We identified approximately 1000 gene promoters (5% of the total), that significantly correlated CpG density with lifespan. The correlations were performed via the phylogenetic least squares method to account for trait similarity by common descent using phylogenetic branch lengths. Gene set enrichment analysis revealed no significantly enriched pathways or processes, consistent with the hypothesis that aging is not under positive selection. However, within both mammals and primates, 95% of the promoters showed a positive correlation between increasing CpG density and species lifespan, and two thirds were shared between the primate subset and mammalian datasets. Thus, these genes may require greater buffering capacity against age-related dysregulation of DNA methylation in longer-lived species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.