ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 83 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multimodal Investigation of Cortico-Basal Ganglia-Thalamo-Cortical (CBGTC) Network Dynamics in Dystonic Patients With Deep Brain Stimulation (DBS)
Precision Neuroimaging of Parkinson's Disease
Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Using Magnetoencephalography to Advance the Science of Parkinson Disease: A Systematic Review.Brain and behavior · 2025Pooled it
- Suppression of pathological oscillations with transcranial focused ultrasound in Parkinson's disease.Nature communications · 2026Trial
- Dorsal-to-ventral imbalance in the superior longitudinal fasciculus mediates methylphenidate's effect on beta oscillations in ADHD.Psychophysiology · 2022Trial
- Cortical-to-pallidal beta cascade underlies network pathophysiology in Parkinson's disease.Cell reports. Medicine · 2026Article
- Acute and Chronic Local Field Potential Recordings in Dystonia-A Systematic Review.Movement disorders clinical practice · 2026Review
- Cortico-pallidal beta dynamics underlie impaired turning in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Parkinson's disease severity is encoded by non-linear oscillatory interactions across cortical-subcortical networks.Scientific reports · 2026Article
- A multi-modal parcellation of human globus pallidus and its implications for symptom prediction and stratification in Parkinson's disease.BMC medicine · 2026Article
- Cortical and basal ganglia beta oscillations and frequency-dependent DBS effects in the A53T Parkinson's disease rat model.NPJ Parkinson's disease · 2026Article
- Article
- Spatial signature of low-frequency network changes accounts for pallidal stimulation outcome in cervical dystonia.EBioMedicine · 2026Article
- Pallidal beta power is associated with depression in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Preoperative Functional Connectivity Predicts Antiparkinson Drug Change after Deep Brain Stimulation.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Functional and Structural Connectivity Correlates of Axial Symptom Outcomes After Pallidal Deep Brain Stimulation in Parkinson's Disease.Brain sciences · 2025Article
- Status dystonicus is a distinct state characterized by pallidal beta-band activity.Nature communications · 2025Article
- Alterations in beta oscillatory activity occur with the emergence of parkinsonian motor signs across the basal ganglia-thalamocortical network.Neurobiology of disease · 2025Article
- Paired Deep Brain Stimuli Elicit Short-Term Facilitation in Globus Pallidus Interna and Subthalamic Nucleus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Modeling and optimizing deep brain stimulation to enhance gait in Parkinson's disease: personalized treatment with neurophysiological insights.NPJ Parkinson's disease · 2025Article
- L-Dopa-induced changes in aperiodic bursts dynamics relate to individual clinical improvement in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Separable global and local beta burst dynamics in motor cortex of primates.bioRxiv : the preprint server for biology · 2025Article
23 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
In Parkinson's disease (PD), subthalamic nucleus beta band oscillations are decreased by therapeutic deep-brain stimulation (DBS) and this has been proposed as important to the mechanism of therapy. The globus pallidus is a common alternative target for PD with similar motor benefits as subthalamic DBS, but effects of pallidal stimulation in PD are not well studied, and effects of pallidal DBS on cortical function in PD are unknown. Here, in 20 PD and 14 isolated dystonia human patients of both genders undergoing pallidal DBS lead implantation, we recorded local field potentials from the globus pallidus and in a subset of these, recorded simultaneous sensorimotor cortex ECoG potentials. PD patients had elevated resting pallidal low beta band (13-20 Hz) power compared with dystonia patients, whereas dystonia patients had elevated resting pallidal theta band (4-8 Hz) power compared with PD. We show that this results in disease-specific patterns of interaction between the pallidum and motor cortex: PD patients demonstrated relatively elevated phase coherence with the motor cortex in the beta band and this was reduced by therapeutic pallidal DBS. Dystonia patients had greater theta band phase coherence. Our results support the hypothesis that specific motor phenomenology observed in movement disorders are associated with elevated network oscillations in specific frequency bands, and that DBS in movement disorders acts in general by disrupting elevated synchronization between basal ganglia output and motor cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.