Evidence map›Paper›PMID 29661927›Full record

ArticleInfection and immunity2018

T Cell-Independent Gamma Interferon and B Cells Cooperate To Prevent Mortality Associated with Disseminated Chlamydia muridarum Genital Tract Infection.

Taylor B Poston, Catherine M O'Connell, Jenna Girardi, Jeanne E Sullivan, Uma M Nagarajan, Anthony Marinov, Amy M Scurlock, Toni Darville

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

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  19. [Role of tumor necrosis factor-α inNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Taylor B PostonDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA tbposton@email.unc.edu.
Catherine M O'ConnellDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
Jenna GirardiDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
Jeanne E SullivanDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
Uma M NagarajanDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
Anthony MarinovDepartment of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Amy M ScurlockDepartment of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Toni DarvilleDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USArkansas Children's Hospital · USChildren's Hospital of Pittsburgh · US

Funding

The UPMC Sexually Transmitted Infections Cooperative Research CenterU19AI084024 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WIESENFELD, HAROLD C · 2009 to 2013
$12.9M
Molecular Mechanisms of Type I IFN Induction during Chlamydia InfectionR01AI067678 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NAGARAJAN, UMA M · 2007 to 2018
$3.5M
NIAID NIH HHS R01 AI067678NIAID NIH HHS U19 AI084024
6 · The paper itself

Abstract

CD4 T cells and antibody are required for optimal acquired immunity to

Indexed as

Chlamydia muridarumAnimalsB-LymphocytesChlamydia InfectionsFemaleHomeodomain ProteinsInterferon-gammaMiceMice, Inbred C57BLPlasmidsReproductive Tract InfectionsT-LymphocytesHomeodomain ProteinsInterferon-gammaRAG-1 proteinB cell responsesChlamydiainterferons

Identifiers

PMID29661927
PMCPMC6013674
OpenAlexW2887857161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.