Evidence map›Paper›PMID 29661879›Full record

ArticleAntimicrobial agents and chemotherapy2018

Accelerating Early Antituberculosis Drug Discovery by Creating Mycobacterial Indicator Strains That Predict Mode of Action.

Maikel Boot, Susanna Commandeur, Amit K Subudhi, Meriem Bahira, Trever C Smith, Abdallah M Abdallah, Mae van Gemert, Joël Lelièvre, Lluís Ballell, Bree B Aldridge and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Transcriptomic responses to antibiotic exposure inAntimicrobial agents and chemotherapy · 2024
    Article
  4. Heterologous Expression ofAntimicrobial agents and chemotherapy · 2021
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Genome-Wide Transcriptional Responses ofFrontiers in microbiology · 2019
    Review
  12. The singularCell surface (Amsterdam, Netherlands) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 4 countries.

Maikel BootDepartment of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Susanna CommandeurDepartment of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Amit K SubudhiDivision of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Meriem BahiraDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Trever C SmithDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Abdallah M AbdallahDivision of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Mae van GemertDepartment of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Joël LelièvreDiseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Lluís BallellDiseases of the Developing World, GlaxoSmithKline, Tres Cantos, Madrid, Spain.
Bree B AldridgeDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Arnab PainDivision of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
Alexander SpeerDepartment of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands.
Wilbert BitterDepartment of Medical Microbiology and Infection Control, VU University Medical Center, Amsterdam, The Netherlands w.bitter@vumc.nl.
Amsterdam UMC Location VUmc · NLKing Abdullah University of Science and Technology · SATufts University · USGlaxoSmithKline (Spain) · ES

Funding

Infectious Disease Training-Pathogenesis/Host ResponseT32AI007329 · NIAID · TUFTS MEDICAL CENTER · PI HU, LINDEN T · 1988 to 2018
$4.1M
Quantitative Design of Multi-drug Regiments for TuberculosisDP2LM011952 · NLM · TUFTS UNIVERSITY BOSTON · PI ALDRIDGE, BREE BEARDSLEY · 2013 to 2018
$2.9M
NIAID NIH HHS T32 AI007329NLM NIH HHS DP2 LM011952
6 · The paper itself

Abstract

Due to the rise of drug-resistant forms of tuberculosis, there is an urgent need for novel antibiotics to effectively combat these cases and shorten treatment regimens. Recently, drug screens using whole-cell analyses have been shown to be successful. However, current high-throughput screens focus mostly on

Indexed as

AnimalsAntitubercular AgentsBase SequenceCell LineCiprofloxacinDrug DiscoveryEthambutolHumansIsoniazidMacrophagesMiceMycobacterium marinumMycobacterium tuberculosisRAW 264.7 CellsRifampinRNA, BacterialAntitubercular AgentsCiprofloxacinEthambutolIsoniazidRifampinRNA, BacterialStreptomycinantibioticsmycobacteriaRNA sequencingstress responses

Identifiers

PMID29661879
PMCPMC6021670
OpenAlexW2797104113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.