Evidence map›Paper›PMID 29661867›Full record

ArticleAntimicrobial agents and chemotherapy2018

Triclosan Is an Aminoglycoside Adjuvant for Eradication of Pseudomonas aeruginosa Biofilms.

Michael M Maiden, Alessandra M Agostinho Hunt, Mitchell P Zachos, Jacob A Gibson, Martin E Hurwitz, Martha H Mulks, Christopher M Waters

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Rational Targeting and gRNA Design for Enhancing Quorum Quenching inComputational and structural biotechnology journal · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Recent Advances in the Control of Clinically Important Biofilms.International journal of molecular sciences · 2022
    Review
  11. Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael M Maiden *Departments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
Alessandra M Agostinho Hunt *Departments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
Mitchell P ZachosDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
Jacob A GibsonDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
Martin E HurwitzDepartment of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, USA.
Martha H MulksDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
Christopher M WatersDepartments of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA watersc3@msu.edu.
Michigan State University · US

Funding

From structure to systems: Understanding cyclic di-GMP control of transcriptionR01GM109259 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WATERS, CHRISTOPHER M · 2015 to 2019
$2.0M
Molecular mechanisms of adaptive diversity in Burkholderia biofilmsR01GM110444 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, VAUGHN · 2015 to 2019
$1.5M
NIGMS NIH HHS R01 GM109259NIGMS NIH HHS R01 GM110444
6 · The paper itself

Abstract

One of the most important clinical obstacles in cystic fibrosis (CF) treatment is antibiotic treatment failure due to biofilms produced by

Indexed as

Adjuvants, PharmaceuticAnti-Bacterial AgentsBiofilmsCystic FibrosisDrug SynergismDrug Therapy, CombinationFatty Acid Synthesis InhibitorsHigh-Throughput Screening AssaysHumansMicrobial Sensitivity TestsPseudomonas aeruginosaTobramycinTriclosanAdjuvants, PharmaceuticAnti-Bacterial AgentsFatty Acid Synthesis InhibitorsTobramycinTriclosanbiofilmpersisterPseudomonas aeruginosatobramycintriclosan

Identifiers

PMID29661867
PMCPMC5971565
OpenAlexW2796679798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.