Evidence map›Paper›PMID 29661838›Full record

Trial reportHypertension (Dallas, Tex. : 1979)2018

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older Adults.

Matthew J Rossman, Jessica R Santos-Parker, Chelsea A C Steward, Nina Z Bispham, Lauren M Cuevas, Hannah L Rosenberg, Kayla A Woodward, Michel Chonchol, Rachel A Gioscia-Ryan, Michael P Murphy and 1 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Hypertension (Dallas, Tex. : 1979), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 281 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
281citing papers in PubMed, 3 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02597023 nacompletednot on this map

The Efficacy of Oral Mitoquinone (MitoQ) Supplementation for Improving Physiological in Middle-aged and Older Adults

TypeinterventionalSponsorUniversity of Colorado, BoulderRan2015 to 2017Enrolled55ConditionsAgingArmsMitoQ, Placebo
NCT05561556 nacompletednot on this mapstarted 2022, after this paper: background citation

Mitochondria Dysfunction as a Contributor to Racial Disparities in Vascular Health and Hypertension

TypeinterventionalSponsorAuburn UniversityRan2022 to 2025Enrolled31ConditionsCardiovascular Diseases, Hypertension, Racism, Vascular DiseasesArmsMitoQ
3 · Its place in the literature

Who cites it

281 citing papers in PubMed, 3 syntheses or guidelines pooled it, 410 citations in OpenAlex.

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  20. Immunoinflammatory mechanisms and emerging therapies for postherpetic neuralgia.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review

221 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Matthew J RossmanFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.) matthew.rossman@colorado.edu.
Jessica R Santos-ParkerFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Chelsea A C StewardFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Nina Z BisphamFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Lauren M CuevasFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Hannah L RosenbergFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Kayla A WoodwardFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Michel ChoncholDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora (M.C., D.R.S.).
Rachel A Gioscia-RyanFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
Michael P Murphyand MRC Mitochondrial Biology Unit, Cambridge, United Kingdom (M.P.M.).
Douglas R SealsFrom the Department of Integrative Physiology, University of Colorado Boulder (M.J.R., J.R.S.-P., C.A.C.S., N.Z.B., L.M.C., H.L.R., K.A.W., R.A.G.-R., D.R.S.).
University of Colorado Boulder · USUniversity of Colorado Anschutz Medical Campus · USWoodward (United States) · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
University of Colorado Aging Training GrantT32AG000279 · NIA · UNIVERSITY OF COLORADO DENVER · PI Kerrie Moreau · 2001 to 2026
$10.1M
MitoQ Supplementation for Improving Vascular Endothelial Function in Older AdultsR21AG049451 · NIA · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2016 to 2017
$431k
MitoQ Supplementation for Improving Vascular Endothelial Function in Older AdultsF32AG053009 · NIA · UNIVERSITY OF COLORADO · PI ROSSMAN, MATTHEW J · 2016 to 2017
$107k
Medical Research Council MC_U105663142Medical Research Council MC_UU_00015/3NCATS NIH HHS UL1 TR001082NIA NIH HHS F32 AG053009NIA NIH HHS R21 AG049451NIA NIH HHS T32 AG000279NIDDK NIH HHS P30 DK048520Wellcome Trust 110158/Z/15/ZWellcome Trust 110159/Z/15/Z
6 · The paper itself

Abstract

Excess reactive oxygen species production by mitochondria is a key mechanism of age-related vascular dysfunction. Our laboratory has shown that supplementation with the mitochondrial-targeted antioxidant MitoQ improves vascular endothelial function by reducing mitochondrial reactive oxygen species and ameliorates arterial stiffening in old mice, but the effects in humans are unknown. Here, we sought to translate our preclinical findings to humans and determine the safety and efficacy of MitoQ. Twenty healthy older adults (60-79 years) with impaired endothelial function (brachial artery flow-mediated dilation <6%) underwent 6 weeks of oral supplementation with MitoQ (20 mg/d) or placebo in a randomized, placebo-controlled, double-blind, crossover design study. MitoQ was well tolerated, and plasma MitoQ was higher after the treatment versus placebo period ( CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02597023.

Indexed as

AgedAntioxidantsBrachial ArteryCross-Over StudiesDietary SupplementsDouble-Blind MethodEndothelium, VascularFemaleFollow-Up StudiesHealthy VolunteersHumansMaleMiddle AgedMitochondriaOxidative StressReactive Oxygen SpeciesAntioxidantsReactive Oxygen Speciesagingarterial stiffnessendotheliummitochondriareactive oxygen species

Identifiers

PMID29661838
PMCPMC5945293
OpenAlexW2796629168

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.