Evidence map›Paper›PMID 29661797›Full record

ArticleBiology open2018

Fank1 and Jazf1 promote multiciliated cell differentiation in the mouse airway epithelium.

Jo-Anne Johnson, Julie K Watson, Marko Z Nikolić, Emma L Rawlins

Open access · goldAbstract read
In one paragraph

Article in Biology open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A lentiviral toolkit to monitor airway epithelial cell differentiation using bioluminescence.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  6. Article
  7. Review
  8. Variants inFrontiers in genetics · 2023
    Article
  9. Motile cilia genetics and cell biology: big results from little mice.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Integrative Copy Number Analysis of Uveal Melanoma Reveals Novel Candidate Genes Involved in Tumorigenesis Including a Tumor Suppressor Role forClinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jo-Anne JohnsonWellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge, CB2 1QN, UK.
Julie K WatsonWellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge, CB2 1QN, UK.
Marko Z NikolićWellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge, CB2 1QN, UK.ORCID http://orcid.org/0000-0001-6304-6848
Emma L RawlinsWellcome Trust/CRUK Gurdon Institute, Wellcome Trust/MRC Stem Cell Institute, Department of Pathology, University of Cambridge, Cambridge, CB2 1QN, UK e.rawlins@gurdon.cam.ac.uk.ORCID http://orcid.org/0000-0001-7426-3792
The Gurdon Institute · GB

Funding

Medical Research Council G0900424Medical Research Council MR/P009581/1Medical Research Council MR/S005579/1Wellcome Trust
6 · The paper itself

Abstract

The airways are lined by secretory and multiciliated cells which function together to remove particles and debris from the respiratory tract. The transcriptome of multiciliated cells has been extensively studied, but the function of many of the genes identified is unknown. We have established an assay to test the ability of over-expressed transcripts to promote multiciliated cell differentiation in mouse embryonic tracheal explants. Overexpression data indicated that

Indexed as

Cell fateCiliaFoxj1LungMcinNotch

Identifiers

PMID29661797
PMCPMC5936064
OpenAlexW2800636472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.