ArticleThe Journal of cell biology1988
Characterization of the thermotolerant cell. II. Effects on the intracellular distribution of heat-shock protein 70, intermediate filaments, and small nuclear ribonucleoprotein complexes.
Article in The Journal of cell biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 194 citations in OpenAlex.
- Article
- Preventive Vaccination with Mesenchymal Stem Cells Protects Mice from Lethal Infection Caused by Herpes Simplex Virus 1.Molecular biology · 2021Article
- Using magnetic particle imaging systems to localize and guide magnetic hyperthermia treatment: tracers, hardware, and future medical applications.Theranostics · 2020Review
- Ergonomics and Beyond: Understanding How Chemical and Heat Exposures and Physical Exertions at Work Affect Functional Ability, Injury, and Long-Term Health.Human factors · 2016Review
- Nuclear Tau and Its Potential Role in Alzheimer's Disease.Biomolecules · 2016Review
- How the nucleus copes with proteotoxic stress.Current biology : CB · 2014Review
- Connexin43 functions as a novel interacting partner of heat shock cognate protein 70.Scientific reports · 2013Article
- Thermal sensitivity of endothelial cells on synthetic vascular graft material.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2012Article
- Effect of heat challenge on peripheral blood mononuclear cell viability: comparison of a tropical and temperate pig breed.Tropical animal health and production · 2011Article
- PNAC: a protein nucleolar association classifier.BMC genomics · 2011Article
- Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts.The Journal of biological chemistry · 2009Article
- Hsp70 localizes differently from chaperone Hsc70 in mouse mesoangioblasts under physiological growth conditions.Journal of molecular histology · 2008Article
- Regulation of stress-induced intracellular sorting and chaperone function of Hsp27 (HspB1) in mammalian cells.The Biochemical journal · 2007Article
- Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Intracellular localization of constitutive and inducible heat shock protein 70 in rat liver after in vivo heat stress.Molecular and cellular biochemistry · 2004Article
- Stress-specific activation and repression of heat shock factors 1 and 2.Molecular and cellular biology · 2001Article
- Specific preinduction of 60-kDa heat shock protein (chaperonin homolog) by TRH does not protect colonic mucosa against acetic acid-induced lesion in rats.Digestive diseases and sciences · 2000Article
- Heat shock-induced arrests in different cell cycle phases of rat C6-glioma cells are attenuated in heat shock-primed thermotolerant cells.Cell proliferation · 2000Article
- Effect of preinduction of heat-shock proteins on acetic acid-induced small intestinal lesions in rats.Digestive diseases and sciences · 1998Article
- Characterisation of a pea hsp70 gene which is both developmentally and stress-regulated.Plant molecular biology · 1997Article
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2 authors at 1 institution in 1 country.
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Abstract
Here we further characterize a number of properties inherent to the thermotolerant cell. In the preceding paper, we showed that the acquisition of the thermotolerant state (by a prior induction of the heat-shock proteins) renders cells translationally tolerant to a subsequent severe heat-shock treatment and thereby results in faster kinetics of both the synthesis and subsequent repression of the stress proteins. Because of the apparent integral role of the 70-kD stress proteins in the acquisition of tolerance, we compared the intracellular distribution of these proteins in both tolerant and nontolerant cells before and after a severe 45 degrees C/30-min shock. In both HeLa and rat embryo fibroblasts, the synthesis and migration of the major stress-induced 72-kD protein into the nucleolus and its subsequent exit was markedly faster in the tolerant cells as compared with the nontolerant cells. Migration of preexisting 72-kD into the nucleolus was shown to be dependent upon heat-shock treatment and independent of active heat-shock protein synthesis. Using both microinjection and immunological techniques, we observed that the constitutive and abundant 73-kD stress protein similarly showed a redistribution from the cytoplasm and nucleus into the nucleolus as a function of heat-shock treatment. We show also that other lesions that occur in cells after heat shock can be prevented or at least minimized if the cells are first made tolerant. Specifically, the heat-induced collapse of the intermediate filament cytoskeleton did not occur in cells rendered thermotolerant. Similarly, the disruption of intranuclear staining patterns of the small nuclear ribonucleoprotein complexes after heat-shock treatment was less apparent in tolerant cells exposed to a subsequent heat-shock treatment.
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