Evidence map›Paper›PMID 29661473›Full record

ArticleCellular immunology2018

Silk fibroin preserves beta cell function under inflammatory stress while stimulating islet cell surface GLUT2 expression.

N Ashari, H W Pang, T Simon, Y Xiong, J M Coburn, J S Bromberg, D L Kaplan, J McLenithan, M J Fontaine

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Multiple Cell Cultures for MRI Analysis.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

N AshariDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
H W PangDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
T SimonDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Y XiongDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
J M CoburnDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
J S BrombergDepartment of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
D L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
J McLenithanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
M J FontaineDepartment of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: mfontaine@som.umaryland.edu.
University of Maryland, Baltimore · USTufts University · US

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
NIBIB NIH HHS P41 EB002520
6 · The paper itself

Abstract

Silk fibroin is a novel biomaterial for enhancing transplanted islet cell function and survival. This study investigated whether silk fibroin may have unique properties that improve islet function in the face of inflammatory-mediated stress during transplantation. Murine islet function was tested in vitro with either silk fibroin or alginate and challenged with inflammatory cytokines. The glucose-stimulated insulin secretion index for all conditions decreased with inflammatory cytokines, but was better preserved for islets exposed to silk compared to those exposed to alginate or medium. GLUT2 transporter expression on the cell surface of islets exposed to silk was increased compared to alginate or medium alone. Upon cytokine stress, a greater percentage of islet cells exposed to silk expressed GLUT2 on their surface. We conclude that preconditioning islets with silk fibroin stimulates islet cell surface GLUT2 expression, an increase, which persists under inflammatory stress, and may improve islet engraftment and function after transplantation.

Indexed as

AlginatesAnimalsFibroinsGlucose Transporter Type 2InflammationInsulin-Secreting CellsIslets of LangerhansIslets of Langerhans TransplantationMaleMiceMice, Inbred C57BLSilkStress, PhysiologicalAlginatesFibroinsGlucose Transporter Type 2SilkGLUT2 expressionInflammatory stressInsulin secretionIslet transplantationSilk fibroin

Identifiers

PMID29661473
PMCPMC7595206
OpenAlexW2798122539

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.