ArticleBritish journal of anaesthesia2018
Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I.
Article in British journal of anaesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 73 citations in OpenAlex.
- A simple, anesthesia-free infusion technique for in vivo metabolic tracing.Science advances · 2026Article
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.British journal of anaesthesia · 2026Article
- Are "GABAergic" Agents Really So Selective for GABA? Implications for Single- versus Multi-Site Hypotheses From Promiscuous Behavior of Anesthetics and Their Molecular Targets In Vitro.Anesthesia and analgesia · 2026Review
- Dose-dependent cerebral metabolic impairment in a swine model of carbon monoxide poisoning.Neurotoxicology · 2026Article
- Article
- A simple, anesthesia-free infusion technique forbioRxiv : the preprint server for biology · 2025Article
- Assessment of a new class of slow γ-aminobutyric acid type A receptor anesthetic on mouse neuronal and astrocyte mitochondrial function.Research square · 2025Article
- NDUFA10-Mediated ATP Reduction in Medial Prefrontal Cortex Exacerbates Burst Suppression in Aged Mice.CNS neuroscience & therapeutics · 2025Article
- A quantum microtubule substrate of consciousness is experimentally supported and solves the binding and epiphenomenalism problems.Neuroscience of consciousness · 2025Article
- Conscious active inference II: Quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles.Computational and structural biotechnology journal · 2025Review
- Advances in research on propofol-induced postoperative cognitive dysfunction via Piezo channels.Frontiers in molecular neuroscience · 2025Review
- Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review.Journal of neuroinflammation · 2024Review
- Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets.Anesthesiology · 2024Review
- Article
- Synapse-Specific Trapping of SNARE Machinery Proteins in the AnesthetizedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Isoflurane lowers the cerebral metabolic rate of oxygen and prevents hypoxia during cortical spreading depolarizationJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Anesthesia and the neurobiology of consciousness.Neuron · 2024Review
- Potassium Leak Channels and Mitochondrial Complex I Interact in Glutamatergic Interneurons of the Mouse Spinal Cord.Anesthesiology · 2024Article
- Xenobiotics Triggering Acute Intermittent Porphyria and Their Effect on Mouse Brain Respiratory Complexes.Journal of xenobiotics · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe mechanisms of action of volatile anaesthetics are unclear. Volatile anaesthetics selectively inhibit complex I in the mitochondrial respiratory chain. Mice in which the mitochondrial complex I subunit NDUFS4 is knocked out [Ndufs4(KO)] either globally or in glutamatergic neurons are hypersensitive to volatile anaesthetics. The volatile anaesthetic isoflurane selectively decreases the frequency of spontaneous excitatory events in hippocampal slices from Ndufs4(KO) mice.
methodsComplex I inhibition by isoflurane was assessed with a Clark electrode. Synaptic function was measured by stimulating Schaffer collateral fibres and recording field potentials in the hippocampus CA1 region.
resultsIsoflurane specifically inhibits complex I dependent respiration at lower concentrations in mitochondria from Ndufs4(KO) than from wild-type mice. In hippocampal slices, after high frequency stimulation to increase energetic demand, short-term synaptic potentiation is less in KO compared with wild-type mice. After high frequency stimulation, both Ndufs4(KO) and wild-type hippocampal slices exhibit striking synaptic depression in isoflurane at twice the 50% effective concentrations (EC
conclusionsVolatile anaesthetics directly inhibit mitochondrial complex I as a primary target, limiting synaptic ATP production, and excitatory vesicle endocytosis and exocytosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.