Evidence map›Paper›PMID 29661224›Full record

ArticleBMC research notes2018

Notch signals modulate lgl mediated tumorigenesis by the activation of JNK signaling.

Maimuna Sali Paul, Ankita Singh, Debdeep Dutta, Mousumi Mutsuddi, Ashim Mukherjee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Drosophila as a Model for Metastasis.Advances in experimental medicine and biology · 2025
    Review
  2. Regulation of Notch signaling by non-muscle myosin II Zipper in Drosophila.Cellular and molecular life sciences : CMLS · 2024
    Article
  3. Notch Transduction in Non-Small Cell Lung Cancer.International journal of molecular sciences · 2020
    Review
  4. Polarity proteins in oncogenesis.Current opinion in cell biology · 2020
    Review
  5. Two-Faced: Roles of JNK Signalling During Tumourigenesis in theFrontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maimuna Sali PaulDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, 221 005, India.
Ankita SinghDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, 221 005, India.
Debdeep DuttaDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, 221 005, India.
Mousumi MutsuddiDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, 221 005, India. mousumi@bhu.ac.in.
Ashim MukherjeeDepartment of Molecular and Human Genetics, Banaras Hindu University, Varanasi, 221 005, India. amukherjee@bhu.ac.in.

Funding

Department of Biotechnology , Ministry of Science and Technology BT/PR14080/BRB/10/805/2010Department of Biotechnology , Ministry of Science and Technology BT/PR14082/BRB/10/806/2010
6 · The paper itself

Abstract

objectivesOncogenic potential of Notch signaling and its cooperation with other factors to affect proliferation are widely established. Notch exhibits a cooperative effect with loss of a cell polarity gene, scribble to induce neoplastic overgrowth. Oncogenic Ras also show cooperative effect with loss of cell polarity genes such as scribble (scrib), lethal giant larvae (lgl) and discs large to induce neoplastic overgrowth and invasion. Our study aims at assessing the cooperation of activated Notch with loss of function of lgl in tumor overgrowth, and the mode of JNK signaling activation in this context.

resultsIn the present study, we use Drosophila as an in vivo model to show the synergy between activated Notch (N

Indexed as

AnimalsCarcinogenesisCell DeathDrosophilaDrosophila ProteinsMAP Kinase Signaling SystemModels, AnimalReceptors, NotchTumor Suppressor ProteinsDrosophila Proteinsl(2)gl protein, DrosophilaN protein, DrosophilaReceptors, NotchTumor Suppressor ProteinsCell deathDrosophilaJNK signalinglglNotchTumor overgrowth

Identifiers

PMID29661224
PMCPMC5902968

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.