ArticleBMC oral health2018
Molecular and clinical analyses of Helicobacter pylori colonization in inflamed dental pulp.
Article in BMC oral health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Oral Helicobacter pylori: a scoping review and pilot study on the PCR-culture detection paradox.Clinical oral investigations · 2026Article
- Distribution of Helicobacter pylori in the Oral Cavity of Patients With Tooth Extractions at Various Locations and Ages.International dental journal · 2026Article
- Review
- Epidemiological status of family-based Helicobacter pylori infection in Yunnan Province, China.BMC gastroenterology · 2025Article
- Advances in 16S rRNA-Based Microbial Biomarkers for Gastric Cancer Diagnosis and Prognosis.Microbial biotechnology · 2025Review
- Effect ofJournal of oral microbiology · 2025Article
- Polymicrobial interactions ofJournal of oral microbiology · 2025Review
- Helicobacter pylori in oral cavity: current knowledge.Clinical and experimental medicine · 2024Review
- The role of periodontitis in cancer development, with a focus on oral cancers.Molecular biology reports · 2024Review
- Characterization of the unique oral microbiome of children harboringJournal of oral microbiology · 2024Article
- The impact ofFrontiers in microbiology · 2023Article
- Detection ofMicroorganisms · 2022Article
- Review
- DNA diagnostics for reliable and universal identification ofWorld journal of gastroenterology · 2021Review
- Distribution ofBiomedicines · 2020Article
- Association between Helicobacter pylori infection and dental pulp reservoirs in Japanese adults.BMC oral health · 2019Article
- Comparison of oral flora before and after triple therapy for Helicobacter pylori eradication in patient with gastric disease.Odontology · 2019Article
- Potential involvement of Helicobacter pylori from oral specimens in overweight body-mass index.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, dental pulp has been considered a possible source of infection of Helicobacter pylori (H. pylori) in children. We previously developed a novel PCR system for H. pylori detection with high specificity and sensitivity using primer sets constructed based on the complete genome information for 48 H. pylori strains. This PCR system showed high sensitivity with a detection limit of 1-10 cells when serial dilutions of H. pylori genomic DNA were used as templates. However, the detection limit was lower (10
methodsNested PCR system was constructed using primer sets designed from the complete genome information of 48 H. pylori strains. The detection limit of the nested PCR system was 1-10 cells using both H. pylori genomic DNA and bacterial DNA isolated from inflamed pulp specimens. Next, distribution of H. pylori was examined using 131 inflamed pulp specimens with the nested PCR system. In addition, association between the detection of H. pylori and clinical information regarding endodontic-infected teeth were investigated. Furthermore, adhesion property of H. pylori strains to human dental fibroblast cells was examined.
resultsH. pylori was present in 38.9% of inflamed pulp specimens using the nested PCR system. H. pylori was shown to be predominantly detected in primary teeth rather than permanent teeth. In addition, samplings of the inflamed pulp were performed twice from the same teeth at 1- or 2-week intervals, which revealed that H. pylori was detected in most specimens in both samplings. Furthermore, H. pylori strains showed adhesion property to human dental fibroblast cells.
conclusionOur results suggest that H. pylori colonizes inflamed pulp in approximately 40% of all cases through adhesion to human dental fibroblast cells.
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