Evidence map›Paper›PMID 29661184›Full record

ArticleLipids in health and disease2018

Genetic variants of SLC12A3 modulate serum lipid profiles in a group of Mongolian pedigree population.

Caiyan An, Junqing Liang, Kejin Zhang, Xiulan Su

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Caiyan AnClinical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China.
Junqing LiangDepartment of Galactophore, Affiliated People's Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
Kejin ZhangKey Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Northwest University, Xi'an, China.
Xiulan SuClinical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, 010050, Inner Mongolia, China. xlsu2014@163.com.ORCID http://orcid.org/0000-0002-5959-9295
Inner Mongolia Medical University · CNInner Mongolia People's Hospital · CNMinistry of Education of the People's Republic of China · CN

Funding

Higher School Science Research Project of Inner Mongolia Autonomous Region No.NJZY14137Natural Science Foundation of Inner Mongolia Autonomous Region No.2015BS0811"Science and Technology Million" project of Inner Mongolia Medical University No. YKD2016KJBW003the National Natural Science Foundation of China No.81260058the National Natural Science Foundation of China No.81760080
6 · The paper itself

Abstract

backgroundThe serum lipid profile, including LDL-C level, is associated with hypertension which is the major cause of cerebrovascular disease (CVD) amounting 30% of global death rate. Previous work also demonstrated important roles of genetic variants of SLC12A3 gene on human CVD, hypertension and other diseases in Mongolian population. However, the relationship between SLC12A3 gene polymorphisms on individuals' lipid profile is still unknown.

methodsA panel of 15 SNPs of SLC12A3 gene was genotyped within a 424 Mongolians pedigree cohort. The associations between SLC12A3 polymorphisms and four lipid profiles were analyzed by family-based association test (FBAT) and confirmed with haplotype analysis.

resultsFrom both single site and haplotype analyses, the results demonstrated a close relationship between SLC12A3 polymorphisms and LDL-C level. Two SNPs, rs5803 and rs711746 showed significant associations with individuals' serum LDL-C level (z = - 2.08, P

conclusionOur results demonstrated the importance of SLC12A3 polymorphisms in individuals' difference about their serum lipid profiles, thereby providing evidence that the genetic variants may contribute to CVD development via modulating person's LDL-C level and blood pressure, in certain contexts.

Indexed as

PedigreeCholesterol, LDLDemographyFamilyFemaleGenetic Association StudiesHaplotypesHumansLipidsMaleMongoliaPhenotypePolymorphism, Single NucleotideSolute Carrier Family 12, Member 3Cholesterol, LDLLipidsSLC12A3 protein, humanSolute Carrier Family 12, Member 3Family- based association test (FBAT)Genetic variantsLow-density lipoprotein cholesterol (LDL-C)Mongolian

Identifiers

PMID29661184
PMCPMC5902855
OpenAlexW2803813398

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.