Evidence map›Paper›PMID 29661151›Full record

ArticleBMC cardiovascular disorders2018

N-terminal pro-B-type natriuretic peptide and microsize myocardial infarction risk in the reasons for geographic and racial differences in stroke study.

Madeline R Sterling, Raegan W Durant, Joanna Bryan, Emily B Levitan, Todd M Brown, Yulia Khodneva, Stephen P Glasser, Joshua S Richman, George Howard, Mary Cushman and 1 more

Open access · goldAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Madeline R SterlingDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, P.O. Box 46, New York, N.Y 10065, USA. mrs9012@med.cornell.edu.
Raegan W DurantDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Joanna BryanDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, P.O. Box 46, New York, N.Y 10065, USA.
Emily B LevitanDepartment of Epidemiology, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Todd M BrownDivision of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Yulia KhodnevaDivision of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Stephen P GlasserDepartment of Internal Medicine, University of Kentucky College of Medicine, Louisville, KY, USA.
Joshua S RichmanDepartment of Surgery, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
George HowardDepartment of Biostatistics, University of Alabama at Birmingham School of Public Health, Birmingham, AL, USA.
Mary CushmanDepartments of Medicine and Pathology, Larner College of Medicine at the University of Vermont, Burlington, VT, USA.
Monika M SaffordDivision of General Internal Medicine, Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, P.O. Box 46, New York, N.Y 10065, USA.
University of Alabama at Birmingham · USCornell University · USUniversity of Kentucky · USUniversity of Vermont · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Weill Cornell Training Program in Health Services ResearchT32HS000066 · AHRQ · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHARLSON, MARY E · 1994 to 2018
$4.7M
Complementary and Integrative Medicine Training ProgramT32AT001161 · NCCIH · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHARLSON, MARY E · 2004 to 2008
$721k
Agency for Healthcare Research and Quality T32HS000066AHRQ HHS T32 HS000066NCCIH NIH HHS T32 AT001161NIDDK NIH HHS P30 DK079626NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundN-terminal pro B-type peptide (NT-proBNP) has been associated with risk of myocardial infarction (MI), but less is known about the relationship between NT-proBNP and very small non ST-elevation MI, also known as microsize MI. These events are now routinely detectable with modern troponin assays and are emerging as a large proportion of all MI. Here, we sought to compare the association of NT-proBNP with risk of incident typical MI and microsize MI in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.

methodsThe REGARDS Study is a national cohort of 30,239 US community-dwelling black and white adults aged ≥ 45 years recruited from 2003 to 2007. Expert-adjudicated outcomes included incident typical MI (definite/probable MI with peak troponin ≥ 0.5 μg/L), incident microsize MI (definite/probable MI with peak troponin < 0.5 μg/L), and incident fatal CHD. Using a case-cohort design, we estimated the hazard ratio of the outcomes as a function of baseline NT-proBNP. Competing risk analyses tested whether the associations of NT-proBNP differed between the risk of incident microsize MI and incident typical MI as well as if the association of NT-proBNP differed between incident non-fatal microsize MI and incident non-fatal typical MI, while accounting for incident fatal coronary heart disease (CHD) as well as heart failure (HF).

resultsOver a median of 5 years of follow-up, there were 315 typical MI, 139 microsize MI, and 195 incident fatal CHD. NT-proBNP was independently and strongly associated with all CHD endpoints, with significantly greater risk observed for incident microsize MI, even after removing individuals with suspected HF prior to or coincident with their incident CHD event.

conclusionNT-proBNP is associated with all MIs, but is a more powerful risk factor for microsize than typical MI.

Indexed as

Black or African AmericanWhite PeopleAgedAged, 80 and overBiomarkersFemaleHeart FailureHumansIncidenceMaleMiddle AgedNatriuretic Peptide, BrainNon-ST Elevated Myocardial InfarctionPeptide FragmentsPredictive Value of TestsPrognosisBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)B-type natriuretic peptideCohort studyCoronary heart diseaseMircosize myocardial infarctionRacial disparities

Identifiers

PMID29661151
PMCPMC5902876
OpenAlexW2804119510

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.