SynthesisNeuroRehabilitation2018
Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review.
Synthesis in NeuroRehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07729761 (Effects of Instability Training on Vestibular Impairment in Post Concussion Combat Athletes), which is not on this map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Instability Training on Vestibular Impairment in Post Concussion Combat Athletes
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Diffusion-Weighted Imaging in Mild Traumatic Brain Injury: A Systematic Review of the Literature.Neuropsychology review · 2023Pooled it
- A Systematic Review of ASL Perfusion MRI in Mild TBI.Neuropsychology review · 2023Pooled it
- Feasibility of superimposed supine cycling and lower body negative pressure as an effective means of prolonging exercise tolerance in individuals experiencing persisting post-concussive symptoms: Preliminary results.Experimental physiology · 2026Trial
- Role of anxiety in exercise intolerance and autonomic nervous system dysfunction post-concussion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Trial
- Autonomic nervous system and endocrine system response to upper or lower cervical spine mobilization in males with persistent post-concussion symptoms: a proof-of-concept trial.The Journal of manual & manipulative therapy · 2024Trial
- Primitive-Reflex Profiling After Sport-Related Concussion: An Athlete-Centered Framework for Testing a Candidate Behavioral State Marker.Brain sciences · 2026Article
- The Integrated Effect of Physical Activity and Sleep Problems on Concussion Symptom Resolution.Journal of sport rehabilitation · 2026Article
- Toward precision rehabilitation in adolescent mild traumatic brain injury: leveraging physiologic data from commercially available smartwatches to identify patient subgroups.medRxiv : the preprint server for health sciences · 2026Article
- The association between concussion and autonomic nervous system responses to a cognitive stressor.The Clinical neuropsychologist · 2026Article
- Utility of Heart Rate Variability and Exertional Task Completion During Recovery of Mild Traumatic Brain Injury in Active Duty Service Members.Military medicine · 2026Article
- Respiratory modulation of neurophysiology and symptoms in athletes with sports-related concussion: a randomized crossover trial.Frontiers in neuroscience · 2026Article
- Cardiovascular and Respiratory Responses During Graded Exercise in Adolescents After Sport-Related Concussion.Sports medicine (Auckland, N.Z.) · 2026Article
- Can symptom-severity phenotypes identify depression risk after mild traumatic brain injury? A cluster-based approach.BMC psychiatry · 2025Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Characterising Postural Orthostatic Tachycardia Syndrome (POTS) triggered by a viral illness compared to concussion or trauma.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Prevalence of Orthostatic Autonomic Dysregulation in Pediatric Concussion.JAMA network open · 2025Article
- Article
- Commentary: are postconcussive symptoms and exercise testing appropriate tools to identify autonomic impairment after mild traumatic brain injury?The Clinical neuropsychologist · 2025Review
- Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms.Journal of personalized medicine · 2025Review
- Early Autonomic Dysfunction in Traumatic Brain Injury: An Article Review on the Impact on Multiple Organ Dysfunction.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent evidence suggests that autonomic nervous dysfunction may be one of many potential factors contributing to persisting post-concussion symptoms.
objectiveThis is the first systematic review to explore the impact of concussion on multiple aspects of autonomic nervous system functioning.
methodsThe methods employed are in compliance with the American Academy of Neurology (AAN) and PRISMA standards. Embase, MEDLINE, PsychINFO, and Science Citation Index literature searches were performed using relevant indexing terms for articles published prior to the end of December 2016. Data extraction was performed by two independent groups, including study quality indicators to determine potential risk for bias according to the 4-tiered classification scheme of the AAN.
resultsThirty-six articles qualified for inclusion in the analysis. Only three studies (one Class II and two Class IV) did not identify anomalies in measures of ANS functioning in concussed populations.
conclusionsThe evidence supports the conclusion that it is likely that concussion causes autonomic nervous system anomalies. An awareness of this relationship increases our understanding of the physical impact of concussion, partially explains the overlap of concussion symptoms with other medical conditions, presents opportunities for further research, and has the potential to powerfully inform treatment decisions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.