Evidence map›Paper›PMID 29660819›Full record

ArticleInfluenza and other respiratory viruses2018

Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells.

Steffen Kunzmann, Christine Krempl, Silvia Seidenspinner, Kirsten Glaser, Christian P Speer, Markus Fehrholz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Influenza and other respiratory viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Modulators of Airway Remodeling: The Role of Caffeine and Calcitriol.International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Steffen KunzmannClinic of Neonatology, Buergerhospital Frankfurt am Main, Frankfurt am Main, Germany.
Christine KremplInstitute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany.
Silvia SeidenspinnerUniversity Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.
Kirsten GlaserUniversity Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.
Christian P SpeerUniversity Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.
Markus FehrholzUniversity Children's Hospital, University of Wuerzburg, Wuerzburg, Germany.ORCID http://orcid.org/0000-0003-2183-2415
Universitätsklinikum Würzburg · DEBürgerhospital Frankfurt am Main · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV-infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV-mediated increase in CTGF mRNA. RSV may be involved in airway remodeling processes by increasing CTGF mRNA expression. Caffeine might abrogate these negative effects and thereby help to restore lung homeostasis.

Indexed as

CaffeineCell LineConnective Tissue Growth FactorEpithelial CellsGene ExpressionHumansRespiratory Syncytial VirusesRNA, MessengerCaffeineCCN2 protein, humanConnective Tissue Growth FactorRNA, MessengerCaffeineCCN2dexamethasonelung remodelingpoly(I:C)

Identifiers

PMID29660819
PMCPMC6086851
OpenAlexW2802834638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.