Evidence map›Paper›PMID 29660439›Full record

ArticleBehavioural brain research2019

Activation of 5-HT

Adam K Klein, Erin M Purvis, Kathy Ayala, Lisette Collins, Jacob T Krug, Matthew S Mayes, Aaron Ettenberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adam K KleinBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.
Erin M PurvisBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.
Kathy AyalaBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.
Lisette CollinsBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.
Jacob T KrugBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.
Matthew S MayesBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA.
Aaron EttenbergBehavioral Pharmacology Laboratory, Department of Psychological and Brain Sciences, University of California, Santa Barbara, CA 93106-9660, USA. Electronic address: aaron.ettenberg@psych.ucsb.edu.
University of California, Santa Barbara · USBehavioral Pharma (United States) · US

Funding

Opponent process properties of cocaineR01DA033370 · NIDA · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI ETTENBERG, AARON · 2013 to 2017
$1.6M
NIDA NIH HHS R01 DA033370
6 · The paper itself

Abstract

Recent work has implicated the Lateral Habenula (LHb) in the production of anxiogenic and aversive states. It is innervated by all the major monoamine neurotransmitter systems and has projections that have been shown to modulate the activity of both dopaminergic and serotonergic brain regions. Cocaine is a stimulant drug of abuse that potentiates neurotransmission in these monoamine systems and recent research suggests that the drug's behavioral effects may be related in part to its actions within the LHb. The present research was therefore devised to test the hypothesis that alterations in serotonin (5-HT) function within the LHb can affect the behavioral response to cocaine. Male rats were fitted with intracranial guide cannula and trained to traverse a straight alleyway once a day for a 1 mg/kg i.v. injection of cocaine. Intra-LHb pretreatment with the 5-HT

Indexed as

Analysis of VarianceAnimalsAnxietyBenzopyransCocaineConditioning, OperantCorrelation of DataDisease Models, AnimalDopamine Uptake InhibitorsDose-Response Relationship, DrugHabenulaLocomotionMaleMaze LearningMorpholinesPyridines2-(((3-(morpholinylmethyl)-2H-chromen-8-yl)oxy)methyl)morpholineBenzopyransCocaineCP 94253Dopamine Uptake InhibitorsMorpholinesPyridinesReceptor, Serotonin, 5-HT1BSerotonin AgentsAnxietyCocaineLateral HabenulaRunwaySelf-administrationSerotonin

Identifiers

PMID29660439
PMCPMC6186203
OpenAlexW2798074472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.