ReviewNeuroscience and biobehavioral reviews2018
RDoC-based categorization of amygdala functions and its implications in autism.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Gaze and social functioning associations in autism spectrum disorder: A systematic review and meta-analysis.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism.Autism research : official journal of the International Society for Autism Research · 2021Pooled it
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Autistic and schizotypal traits exhibit similarities in their impact on mentalization and adult attachment impairments: a cross-sectional study.BMC psychiatry · 2024Article
- Prenatal immune activation in mice induces long-term alterations in brain mitochondrial function.Translational psychiatry · 2024Article
- Social Dysfunction and Neural Processing of Emotional Valence Across Depressive and Anxiety Disorders.Depression and anxiety · 2024Article
- Social Withdrawal, Loneliness, and Health in Schizophrenia: Psychological and Neural Mechanisms.Schizophrenia bulletin · 2023Article
- Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: preliminary findings in autistic vs non-autistic women.Social cognitive and affective neuroscience · 2022Article
- Altered Development of Amygdala-Connected Brain Regions in Males and Females with Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Breakdown of utilitarian moral judgement after basolateral amygdala damage.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Association of Amygdala Development With Different Forms of Anxiety in Autism Spectrum Disorder.Biological psychiatry · 2022Article
- Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation.Molecular psychiatry · 2021Article
- Sex Differences in the Amygdala Resting-State Connectome of Children With Autism Spectrum Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Circuits for social learning: A unified model and application to Autism Spectrum Disorder.Neuroscience and biobehavioral reviews · 2019Review
- Lesion Studies in Contemporary Neuroscience.Trends in cognitive sciences · 2019Review
- Prenatal Stress and Maternal Immune Dysregulation in Autism Spectrum Disorders: Potential Points for Intervention.Current pharmaceutical design · 2019Review
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3 authors.
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Abstract
Confusion endures as to the exact role of the amygdala in relation to autism. To help resolve this we turned to the NIMH's Research Domain Criteria (RDoC) which provides a classification schema that identifies different categories of behaviors that can turn pathologic in mental health disorders, e.g. autism. While RDoC incorporates all the known neurobiological substrates for each domain, this review will focus primarily on the amygdala. We first consider the amygdala from an anatomical, historical, and developmental perspective. Next, we examine the different domains and constructs of RDoC that the amygdala is involved in: Negative Valence Systems, Positive Valence Systems, Cognitive Systems, Social Processes, and Arousal and Regulatory Systems. Then the evidence for a dysfunctional amygdala in autism is presented with a focus on alterations in development, prenatal valproic acid exposure as a model for ASD, and changes in the oxytocin system therein. Finally, a synthesis of RDoC, the amygdala, and autism is offered, emphasizing the task of disambiguation and suggestions for future research.
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