ArticleCryobiology2018
Vitrification tendency and stability of DP6-based vitrification solutions for complex tissue cryopreservation.
Article in Cryobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cryopreservation of biological materials: applications and economic perspectives.In vitro cellular & developmental biology. Animal · 2026Review
- Thermomechanics analysis of cryopreservation by vitrification of the popliteal artery.PloS one · 2026Article
- Multi-view cryomacroscopy: A new device for study of cryopreservation by vitrification.Cryobiology · 2025Article
- Physical vitrification and nanowarming at liter-scale CPA volumes: toward organ cryopreservation.Nature communications · 2025Article
- Kidney tissue loading reduces the critical cooling and warming rates of VS55 and VMP cryoprotective solutions.Cryobiology · 2024Article
- Vitreous tissue cryopreservation using a blood vessel model and cryomacroscopy for scale-up studies: Observations and mathematical modeling.Cryobiology · 2024Article
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- Article
- Cryopreservation by Directional Freezing and Vitrification Focusing on Large Tissues and Organs.Cells · 2022Review
- Thermal Analyses of Nanowarming-Assisted Recovery of the Heart From Cryopreservation by Vitrification.Journal of heat transfer · 2022Article
- Ultra-Rapid Laser Calorimetry for the Assessment of Crystallization in Low-Concentration Cryoprotectants.Journal of heat transfer · 2022Article
- Cryopreservation of Animals and Cryonics: Current Technical Progress, Difficulties and Possible Research Directions.Frontiers in veterinary science · 2022Review
- Analysis of crystallization during rewarming in suboptimal vitrification conditions: a semi-empirical approach.Cryobiology · 2021Article
- A Roadmap to Cardiac Tissue-Engineered Construct Preservation: Insights from Cells, Tissues, and Organs.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Principles of Ice-Free Cryopreservation by Vitrification.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Diffusion Limited Cryopreservation of Tissue with Radiofrequency Heated Metal Forms.Advanced healthcare materials · 2020Article
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- Thermal analysis of marginal conditions to facilitate cryopreservation by vitrification using a semi-empirical approach.Cryobiology · 2019Article
- New Approaches to Cryopreservation of Cells, Tissues, and Organs.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2019Review
- Analysis of polarized-light effects in glass-promoting solutions with applications to cryopreservation and organ banking.PloS one · 2018Article
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Authors and funding
5 authors.
Funding
Abstract
Vitrification tendency and stability of the amorphous state were analyzed by means of differential scanning calorimetry (DSC) for the vitrification solution DP6, with and without additional solutes to enhance ice suppression. This study is a part of an ongoing research effort to characterize the thermophysical and mechanical properties of DP6 and its derivatives, and their qualities as cryoprotective solutions. DP6 was determined to have a critical cooling rate necessary to ensure vitrification of 2.7 °C/min. The following additional solutions were tested: DP6 + 6% (2R, 3R) 2,3-butanediol, DP6 + 6% 1,3-cyclohexanediol, DP6 + 6% (0.175M) sucrose, DP6 + 12% PEG 400, and DP6 + 17.1% (0.5 M) sucrose. The additives decreased the critical cooling rate of the DP6 solution to rates below 1 °C/min that were not quantifiable by the DSC techniques used. The following critical warming rates necessary to avoid devitrification were identified for DP6 and the modified solutions, respectively: 189 °C/min, 5 °C/min, ≈ 1 °C/min, 15 °C/min, <1 °C/min, and <1 °C/min. Glass transition temperatures and melting temperatures were also measured. Sucrose was the least effective additive on a per mass basis, with 1,3-cyclohexanediol appearing to be the most effective additive for suppressing ice formation in DP6.
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