ArticleGenes, brain, and behavior2019
Polygenic risk for psychiatric disorders correlates with executive function in typical development.
Article in Genes, brain, and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Executive functions as a transdiagnostic endophenotype in developmental psychopathology.Molecular psychiatry · 2026Review
- Ethnic Identity Profiles Among Adolescents in the ABCD Study: Associations with Resting State Functional Connectivity and Perceived Discrimination.bioRxiv : the preprint server for biology · 2025Article
- How do 3-year-olds do on the NIH Toolbox Cognitive Battery?Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2023Article
- Polygenic risk for ADHD and ASD and their relation with cognitive measures in school children.Psychological medicine · 2022Article
- A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics.BMC medicine · 2021Article
- A preliminary investigation of childhood anxiety/depressive symptomatology and working memory across multiple units of analysis.Psychiatry research · 2021Article
- Measurement of executive functioning with the National Institute of Health Toolbox and the association to anxiety/depressive symptomatology in childhood/adolescence.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2020Article
- Cumulative Influence of Inflammatory Response Genetic Variation on Long-Term Neurobehavioral Outcomes after Pediatric Traumatic Brain Injury Relative to Orthopedic Injury: An Exploratory Polygenic Risk Score.Journal of neurotrauma · 2020Article
- Autism spectrum disorder polygenic scores are associated with every day executive function in children admitted for clinical assessment.Autism research : official journal of the International Society for Autism Research · 2020Article
- Neural correlates of polygenic risk score for autism spectrum disorders in general population.Brain communications · 2020Article
- Investigating genetic links between grapheme-colour synaesthesia and neuropsychiatric traits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
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Authors and funding
9 authors.
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Abstract
Executive functions are a diverse and critical suite of cognitive abilities that are often disrupted in individuals with psychiatric disorders. Despite their moderate to high heritability, little is known about the molecular genetic factors that contribute to variability in executive functions and how these factors may be related to those that predispose to psychiatric disorders. We examined the relationship between polygenic risk scores built from large genome-wide association studies of psychiatric disorders and executive functioning in typically developing children. In our discovery sample (N = 417), consistent with previous reports on general cognitive abilities, polygenic risk for autism spectrum disorder was associated with better performance on the Dimensional Change Card Sort test from the NIH Cognition Toolbox, with the largest effect in the youngest children. Polygenic risk for major depressive disorder was associated with poorer performance on the Flanker test in the same sample. This second association replicated for performance on the Penn Conditional Exclusion Test in an independent cohort (N = 3681). Our results suggest that the molecular genetic factors contributing to variability in executive function during typical development are at least partially overlapping with those associated with psychiatric disorders, although larger studies and further replication are needed.
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