ArticleSchizophrenia bulletin2019
Data-Driven Analysis of Functional Connectivity Reveals a Potential Auditory Verbal Hallucination Network.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- The Involvement of Thalamic Nuclei in Schizophrenia Patients with and Without Auditory Verbal Hallucinations: A Brain Morphometry Study.Brain sciences · 2025Article
- Resting-state functional connectivity correlates of brain structural aging in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia.Frontiers in psychiatry · 2025Article
- A working model of neural activity and phenomenal experience in psychosis.Molecular psychiatry · 2024Review
- Correlation Between Cortical Thickness Abnormalities of the Olfactory Sulcus and Olfactory Identification Disorder and Persistent Auditory Verbal Hallucinations in Chinese Patients With Chronic Schizophrenia.Schizophrenia bulletin · 2024Article
- Sex differences in default mode network connectivity in healthy aging adults.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neurocognitive bases of self-monitoring of inner speech in hallucination prone individuals.Scientific reports · 2023Article
- A schizophrenia study based on multi-frequency dynamic functional connectivity analysis of fMRI.Frontiers in human neuroscience · 2023Article
- Abnormal interhemispheric and intrahemispheric functional connectivity dynamics in drug-naïve first-episode schizophrenia patients with auditory verbal hallucinations.Human brain mapping · 2022Article
- Graph-Based Motion Artifacts Detection Method from Head Computed Tomography Images.Sensors (Basel, Switzerland) · 2022Article
- Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: aTranslational psychiatry · 2022Article
- Atypical Intrinsic Hemispheric Interaction Associated with Autism Spectrum Disorder Is Present within the First Year of Life.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations.Frontiers in molecular neuroscience · 2022Article
- Altered dynamic functional connectivity of auditory cortex and medial geniculate nucleus in first-episode, drug-naïve schizophrenia patients with and without auditory verbal hallucinations.Frontiers in psychiatry · 2022Article
- Brain functional connectivity analysis based on multi-graph fusion.Medical image analysis · 2021Article
- White Matter Microstructural Abnormalities in the Broca's-Wernicke's-Putamen "Hoffman Hallucination Circuit" and Auditory Transcallosal Fibers in First-Episode Psychosis With Auditory Hallucinations.Schizophrenia bulletin · 2021Article
- Training-Dependent Change in Content of Association in Appetitive Pavlovian Conditioning.Frontiers in behavioral neuroscience · 2021Article
- The Etiology of Auditory Hallucinations in Schizophrenia: From Multidimensional Levels.Frontiers in neuroscience · 2021Review
- Differences in functional connectivity density among subtypes of schizophrenic auditory hallucination.Brain imaging and behavior · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Schizophrenia is a severe global health problem, with over half of such patients experiencing auditory verbal hallucinations (AVHs). A better understanding of the neural correlates differentiating patients experiencing AVHs from patients not experiencing AVHs and healthy controls may identify targets that lead to better treatment strategies for AVHs. Employing 2 data-driven, voxel-based measure of functional connectivity, we studied 46 patients with schizophrenia or schizoaffective disorder (28 experiencing AVHs and 18 not experiencing AVHs). Twenty healthy controls matched for age, gender, ethnicity, education level, handedness, and estimated verbal intelligence were included for comparison. The intrinsic connectivity distribution (ICD) was used to model each voxel's connectivity to the rest of the brain using a Weibull distribution. To investigate lateralization of connectivity, we used cross-hemisphere ICD, a method that separates the contribution of each hemisphere to interrogate connectivity laterality. Patients with AVHs compared with patients without AVHs exhibited significantly decreased whole-brain connectivity in the medial prefrontal cortex and posterior cingulate cortex, less lateralized connectivity in left putamen, and more lateralized connectivity in left interior frontal gyrus. Correlations with Auditory Hallucination Rating Scale (AHRS) and post hoc seed connectivity analyses revealed significantly altered network connectivity. Using the results from all analyses comparing the patient groups and correlations with AHRS, we identified a potential AVH network, consisting of 25 nodes, showing substantial overlap with the default mode network and language processing networks. This network as a whole, instead of individual nodes, may represent actionable targets for interventions.
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