ArticleToxicological sciences : an official journal of the Society of Toxicology2018
Respirable Uranyl-Vanadate-Containing Particulate Matter Derived From a Legacy Uranium Mine Site Exhibits Potentiated Cardiopulmonary Toxicity.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Contribution of arsenic and uranium in private wells and community water systems to urinary biomarkers in US adults: The Strong Heart Study and the Multi-Ethnic Study of Atherosclerosis.Journal of exposure science & environmental epidemiology · 2024Pooled it
- From combustion to consequence: respiratory health concerns from primary and aged smoke at the wildland-urban interface.Frontiers in public health · 2026Review
- Extracellular vesicle proteomic expression is influenced by mining tenure in former uranium miners.Environmental research · 2025Article
- Advancements in heavy metal detection using microneedle array technology.Toxicology mechanisms and methods · 2025Article
- Uranium exposure and kidney tubule biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA).Environmental research · 2025Article
- Pro-inflammatory effects of inhaled Great Salt Lake dust particles.Particle and fibre toxicology · 2025Article
- Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles.Research square · 2024Article
- Single Cell Analysis of Human Colonoids Exposed to Uranium-Bearing Dust.Environmental health perspectives · 2024Article
- Detecting radioactive particles in complex environmental samples using real-time autoradiography.Scientific reports · 2024Article
- US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants.Journal of exposure science & environmental epidemiology · 2024Review
- Preterm Birth and Metal Mixture Exposure among Pregnant Women from the Navajo Birth Cohort Study.Environmental health perspectives · 2023Article
- Meteorological data source comparison-a case study in geospatial modeling of potential environmental exposure to abandoned uranium mine sites in the Navajo Nation.Environmental monitoring and assessment · 2023Article
- Influence of Impurities from Manufacturing Process on the Toxicity Profile of Boron Nitride Nanotubes.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- The immunotoxicity of natural and depleted uranium: From cells to people.Toxicology and applied pharmacology · 2022Review
- Effects of Different Concentrations of Oil Mist Particulate Matter on Pulmonary Fibrosis In Vivo and In Vitro.Toxics · 2022Article
- The fate of inhaled uranium-containing particles upon clearance to gastrointestinal tract.Environmental science. Processes & impacts · 2022Article
- Lung-Based, Exosome Inhibition Mediates Systemic Impacts Following Particulate Matter Exposure.Toxics · 2022Article
- A mass-balance approach to evaluate arsenic intake and excretion in different populations.Environment international · 2022Article
- Uptake and Toxicity of Respirable Carbon-Rich Uranium-Bearing Particles: Insights into the Role of Particulates in Uranium Toxicity.Environmental science & technology · 2021Article
- Mine-site derived particulate matter exposure exacerbates neurological and pulmonary inflammatory outcomes in an autoimmune mouse model.Journal of toxicology and environmental health. Part A · 2021Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
Abstract
Exposure to windblown particulate matter (PM) arising from legacy uranium (U) mine sites in the Navajo Nation may pose a human health hazard due to their potentially high metal content, including U and vanadium (V). To assess the toxic impact of PM derived from Claim 28 (a priority U mine) compared with background PM, and consider the putative role of metal species U and V. Two representative sediment samples from Navajo Nation sites (Background PM and Claim 28 PM) were obtained, characterized in terms of chemistry and morphology, and fractioned to the respirable (≤ 10 μm) fraction. Mice were dosed with either PM sample, uranyl acetate, or vanadyl sulfate via aspiration (100 µg), with assessments of pulmonary and vascular toxicity 24 h later. Particulate matter samples were also examined for in vitro effects on cytotoxicity, oxidative stress, phagocytosis, and inflammasome induction. Claim 28 PM10 was highly enriched with U and V and exhibited a unique nanoparticle ultrastructure compared with background PM10. Claim 28 PM10 exhibited enhanced pulmonary and vascular toxicity relative to background PM10. Both U and V exhibited complementary pulmonary inflammatory potential, with U driving a classical inflammatory cytokine profile (elevated interleukin [IL]-1β, tumor necrosis factor-α, and keratinocyte chemoattractant/human growth-regulated oncogene) while V preferentially induced a different cytokine pattern (elevated IL-5, IL-6, and IL-10). Claim 28 PM10 was more potent than background PM10 in terms of in vitro cytotoxicity, impairment of phagocytosis, and oxidative stress responses. Resuspended PM10 derived from U mine waste exhibit greater cardiopulmonary toxicity than background dusts. Rigorous exposure assessment is needed to gauge the regional health risks imparted by these unremediated sites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.