ArticleMolecular biology and evolution2018
Neutral Theory and Phenotypic Evolution.
Article in Molecular biology and evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Cell-specific gene expression plasticity in response to hypoxia promotes high-altitude adaptive evolution.Science China. Life sciences · 2026Article
- Ancestry informative markers in indigenous populations from Brazil.Scientific reports · 2026Article
- Repeatability of gene expression evolution in experimental environmental adaptation.Nature communications · 2026Article
- Transcriptomic and proteomic effects of gene deletion are not evolutionarily conserved.Genome research · 2025Article
- Neutral drift upon threshold-like selection promotes variation in antibiotic resistance phenotype.Nature communications · 2024Article
- Aridification and major geotectonic landscape change shaped an extraordinary species radiation across a world's extreme elevational gradient.Communications biology · 2024Article
- A new perspective on microRNA-guided gene regulation specificity, and its potential generalization to transcription factors and RNA-binding proteins.Nucleic acids research · 2024Review
- Where the "ruber" Meets the Road: Using the Genome of the Red Diamond Rattlesnake to Unravel the Evolutionary Processes Driving Venom Evolution.Genome biology and evolution · 2024Article
- The role of neutral and adaptive evolutionary processes on patterns of genetic diversity across small cave-dwelling populations of Icelandic Arctic charr (Ecology and evolution · 2024Article
- The metabolic domestication syndrome of budding yeast.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Principles of metabolome conservation in animals.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Environmental selection, rather than neutral processes, best explain regional patterns of diversity in a tropical rainforest fish.Heredity · 2023Article
- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- Article
- Skull variation in Afro-Eurasian monkeys results from both adaptive and non-adaptive evolutionary processes.Scientific reports · 2022Article
- Rapid Intraspecies Evolution of Fitness Effects of Yeast Genes.Genome biology and evolution · 2022Article
- Mammalian splicing divergence is shaped by drift, buffering inLife science alliance · 2022Article
- Non-Darwinian Molecular Biology.Frontiers in genetics · 2022Review
- Meta-analysis: Congruence of genomic and phenotypic differentiation across diverse natural study systems.Evolutionary applications · 2021Article
- Constructive Neutral Evolution 20 Years Later.Journal of molecular evolution · 2021Review
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1 author.
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Abstract
Although the neutral theory of molecular evolution was proposed to explain DNA and protein sequence evolution, in principle it could also explain phenotypic evolution. Nevertheless, overall, phenotypes should be less likely than genotypes to evolve neutrally. I propose that, when phenotypic traits are stratified according to a hierarchy of biological organization, the fraction of evolutionary changes in phenotype that are adaptive rises with the phenotypic level considered. Consistently, molecular traits are frequently found to evolve neutrally whereas a large, random set of organismal traits were recently reported to vary largely adaptively. Many more studies of unbiased samples of phenotypic traits are needed to test the general validity of this hypothesis.
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