ArticleThe Journal of infectious diseases2018
Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV Transmission by Vector Bite to Vertebrate Host.
Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- ZIKV NS3 disrupts Nrf2-mediated antioxidant defense and drives vascular smooth muscle cell damage and vascular dysfunction.Zoological research · 2026Article
- The consequence of simultaneous and sequential coinfections ofFrontiers in cellular and infection microbiology · 2026Article
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Sequential macrophage DENV and ZIKV infection shows differential expression of CD86, IFN-β, and regulation of TNF-α and IL-1β depending on DENV serotype.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Virome of Terrestrial Mammals and Bats from Southern Brazil: Circulation of New Putative Members of thePathogens (Basel, Switzerland) · 2025Article
- Review
- The impact of blood on vector-borne diseases with emphasis on mosquitoes and sand flies.Trends in parasitology · 2025Review
- Estimating per-infection cost and burden for dengue and Zika as a function of antibody-dependent enhancement.PLoS neglected tropical diseases · 2025Article
- WNV and SLEV coinfection in avian and mosquito hosts: impact on viremia, antibody responses, and vector competence.Journal of virology · 2024Article
- Biased virus transmission following sequential coinfection of Aedes aegypti with dengue and Zika viruses.PLoS neglected tropical diseases · 2024Article
- Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts.Nature communications · 2024Article
- Temperature affects viral kinetics and vectorial capacity of Aedes aegypti mosquitoes co-infected with Mayaro and Dengue viruses.Parasites & vectors · 2024Article
- Dengue and zika seropositivity, burden, endemicity, and cocirculation antibodies in Nigeria.Annals of medicine · 2023Article
- Detection of DENV-2 and ZIKV coinfection in southeastern Brazil by serum and urine testing.Medical microbiology and immunology · 2023Article
- Co-infection of dengue and Zika viruses mutually enhances viral replication in the mosquito Aedes aegypti.Parasites & vectors · 2023Article
- Article
- Prevalence of arboviruses and other infectious causes of skin rash in patients treated at a tertiary health unit in the Brazilian Amazon.PLoS neglected tropical diseases · 2022Article
- Spatio-temporal clusters and patterns of spread of dengue, chikungunya, and Zika in Colombia.PLoS neglected tropical diseases · 2022Article
- Widespread interspecific phylogenetic tree incongruence between mosquito-borne and insect-specific flaviviruses at hotspots originally identified in Zika virus.Virus evolution · 2022Article
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with ≥2 arboviruses. Methods: A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results: A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions: This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.
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Registered trials
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