ArticleThe Journal of antimicrobial chemotherapy2018
Mobile colistin resistance gene mcr-5 in porcine Aeromonas hydrophila.
Article in The Journal of antimicrobial chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Aeromonas in South Asia: genomic insights into an environmental pathogen and reservoir of antimicrobial resistance.Nature communications · 2026Article
- Antibiotic Abuse in Ornamental Fish: An Overlooked Reservoir for Antibiotic Resistance.Microorganisms · 2025Review
- First report of multidrug-resistant carbapenemase-producingMicrobiology spectrum · 2024Article
- A Review on Colistin Resistance: An Antibiotic of Last Resort.Microorganisms · 2024Review
- Two colistin resistance-producingFrontiers in microbiology · 2024Article
- Characterization of Third Generation Cephalosporin- and Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Frequent convergence ofEmerging microbes & infections · 2022Article
- The variants of polymyxin susceptibility in different species of genusFrontiers in microbiology · 2022Article
- Contribution of the EnvZ/OmpR two-component system to growth, virulence and stress tolerance of colistin-resistantFrontiers in microbiology · 2022Article
- Global epidemiology, genetic environment, risk factors and therapeutic prospects ofFrontiers in cellular and infection microbiology · 2022Review
- Colistin ResistantVeterinary sciences · 2021Review
- Characterisation of mobile colistin resistance genes (mcr-3 and mcr-5) in river and storm water in regions of the Western Cape of South Africa.Antimicrobial resistance and infection control · 2021Article
- Colistin Resistance inInternational journal of molecular sciences · 2021Review
- Current Update on Intrinsic and Acquired Colistin Resistance Mechanisms in Bacteria.Frontiers in medicine · 2021Review
- A Novel Transposon, TnInfection and drug resistance · 2020Article
- An overview of colistin resistance, mobilized colistin resistance genes dissemination, global responses, and the alternatives to colistin: A review.Veterinary world · 2019Review
- Conjugative IncX1 Plasmid Harboring Colistin Resistance GeneAntimicrobial agents and chemotherapy · 2019Article
- Functional Characterization of a Miniature Inverted Transposable Element at the Origin ofAntimicrobial agents and chemotherapy · 2019Article
- A Genomic, Evolutionary, and Mechanistic Study of MCR-5 Action Suggests Functional Unification across the MCR Family of Colistin Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Characterization ofAntimicrobial agents and chemotherapy · 2019Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To characterize the mobile colistin resistance gene mcr-5 in Aeromonas hydrophila from backyard pigs in rural areas of China. Methods: Pig faecal samples from 194 households were directly tested for the presence of mcr-5 by PCR assay and the phenotypic antimicrobial susceptibility profiles of the mcr-5-positive isolates were determined using the broth dilution method. The genomic location and transferability of mcr-5 were analysed by S1-PFGE with Southern blotting and DNA hybridization, and natural transformation, respectively. One strain isolated from an mcr-5-positive sample was subjected to WGS and the stability of the mcr-5-harbouring plasmid over successive generations was examined by subculturing. Results: One mcr-5-positive A. hydrophila isolate showing resistance, with a colistin MIC of 4 mg/L, was isolated from a backyard pig faecal sample. mcr-5 was located on a 7915 bp plasmid designated pI064-2, which could naturally transform into a colistin-susceptible A. hydrophila strain of porcine origin and mediated colistin resistance in both the original isolate and its transformants. The plasmid backbone (3790 bp) of pI064-2 showed 81% nucleotide sequence identity to the corresponding region of the ColE2-type plasmid pAsa1 from Aeromonas salmonicida, while similar replication primases are widely distributed among aeromonads, Enterobacteriaceae and Pseudomonas species. Conclusions: To the best of our knowledge, this is the first identification of the novel colistin resistance gene mcr-5 in an A. hydrophila isolate from the faeces of a backyard pig. mcr-5 is expected to be able to disseminate among different bacterial species and genera.
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