ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Body Composition Remodeling and Incident Mobility Limitations in African Ancestry Men.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- The association between muscle mass and change in physical functioning in older adults: a systematic review and meta-analysis of prospective studies.European geriatric medicine · 2025Pooled it
- Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men.GeroScience · 2026Article
- Myosteatosis: an emerging biomarker of aging.Frontiers in aging · 2026Review
- Thigh and Calf Myosteatosis are Strongly Associated with Muscle and Physical Function in African Caribbean Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Body Composition Across the Adult Lifespan in African Caribbean Men: The Tobago Longitudinal Study of Aging.The Journal of frailty & aging · 2022Article
- Adverse muscle composition predicts all-cause mortality in the UK Biobank imaging study.Journal of cachexia, sarcopenia and muscle · 2021Article
- Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM.Journal of rehabilitation medicine · 2021Article
- Putative Cut-Points in Sarcopenia Components and Incident Adverse Health Outcomes: An SDOC Analysis.Journal of the American Geriatrics Society · 2020Observational
- Sarcopenia Characteristics Are Associated with Incident Mobility Limitations in African Caribbean Men: The Tobago Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundMobility limitations are common, with higher prevalence in African Americans compared with whites, and are associated with disability, institutionalization, and death. Aging is associated with losses of lean mass and a shift to central adiposity, which are more pronounced in African Americans. We aimed to examine the association of body composition remodeling with incident mobility limitations in older men of African ancestry.
methodsSeven-year changes in body composition were measured using peripheral quantitative computed tomography (pQCT) of the calf and whole-body dual x-ray absorptiometry (DXA) in 505 African ancestry men aged ≥60 years and free of self-reported mobility limitations at baseline. Self-reported incident mobility limitations were assessed at 7-year follow-up. Odds of developing mobility limitations associated with baseline and change in body composition were quantified using separate logistic regression models.
resultsSeventy-five men (14.9%) developed incident mobility limitations over 6.2 ± 0.6 years. Baseline body composition was not associated with incident mobility limitations. After adjustment for covariates, gaining total and intermuscular fat were associated with incident mobility limitations (odds ratio [OR]: 1.60; 95% confidence interval [CI]: 1.21-2.13; OR: 1.51; 95% CI: 1.18-1.94). Changes in DXA lean mass were not related to mobility limitations; however, maintaining pQCT calf muscle area was protective against mobility limitations (OR: 0.65; 95% CI: 0.48-0.87).
conclusionsIncreases in body fat, and particularly intermuscular fat, and decreases in calf skeletal muscle area were associated with a higher risk of developing mobility limitations. Our findings emphasize the importance of body composition remodeling in the development of mobility limitations among African ancestry men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.